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Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel
Femodene contains gestodene, the most potent
The protein binding of ethinylestradiol (EE2), gestodene (GEST) and 3-keto-desogestrel (KDG) has been determined by ultrafiltration in the serum of women who had either
x Abstract Aims: Our objective was to study in vivo the role of CYP2C and CYP3A4 in the disposition of 3-keto-desogestrel after administration
Following oral administration, the relative bioavailability of desogestrel, as measured by serum levels of 3-keto-desogestrel, is approximately 84%
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Gestodene versus desogestrel (monophasic) (see additional file 1) This comparison has the largest number of studies (seven) and number of women (n = 5624) included [ 11 , 13 , 16 , 19 , 27 - 29 ]
Europe PubMed Central
Synonyms: 3-keto-desogestrel | Implanon® | Nexplanon® | ORG-3236 etonogestrel is an approved drug (FDA (2006), EMA (2009)) Compound class: Synthetic organic Comment: Etonogestrel is the active metabolite of the inactive prodrug desogestrel
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The Figure 1 PIP: A synthetic form of desogestrel, a gonane progestin, was developed because desogestrel's enhanced selectivity eliminates adverse, androgen-dependent, metabolic effects at contraceptive doses
Such performance was found in the PC 4 cm implants and the ORG 4
Eight healthy women using one Silastic implant of 30 mm length filled with 3-keto desogestrel, the active metabolite of desogestrel, were studied for 36-664 days
scientific article published in June 1989
19 March 2018
: 258-936-2
Europe PubMed Central