Tamoxifen-associated macular abnormalities and MacTel type 2 are rare and usually asymptomatic
February 13, 2007 –- A new study has found that tamoxifen use may lead to eye problems among middle-aged women older than 50 years
Clinical findings were symmetric with central pigmentary alterations (A “Tamoxifen has long been known to cause eye problems, including dryness, irritation, cataracts, and deposits in the retina, in the area of the macula, that result in macular edema,” said K
According to the diagnostic criteria, 30 patients (12
Purpose To present a case of tamoxifen retinopathy on a 57-year-old woman
Tamoxifen (TAM) is a selective estrogen receptor modulator that is used in the treatment of breast cancer
A case of tamoxifen retinopathy examined with spectral-domain optical coherence tomography (SD-OCT) is presented
↑ Lonn LI
4–290
PRIF analyses the causes of international and intrastate conflicts and looks for ways to solve them
Tamoxifen is a selective estrogen receptor modulator that has been used for the treatment of breast cancer since the early
The appearances were consistent with a diagnosis of crystalline/tamoxifen retinopathy and treatment was discontinued
Low-dose tamoxifen ocular toxicity is well documented and its incidence was reported to be 6
Retinopathy is characterized by bilateral, fine, superficial, and yellow crystalline deposits in the inner retinal layers (IRL) and punctate
For people with a history of eye problems: Tamoxifen can further Tamoxifen is a non-steroidal antioestrogen agent that is widely used to reduce the risk of developing recurrent breast cancer in high-risk patients
The distant visual acuity was 20/40 for the right eye and 20/100 for the left eye
As there are estrogen receptors in the retina, retinal pigment epithelium, and choroid, these tissues may also be affected by TAM
1 Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
Results
Macular telangiectasia type 2 is a bilateral, multifactorial macular useful to tamoxifen-related changes in the retina date back to 1977
Bilateral, symmetric crystalline deposits were present at the macula (A, B)
It’s a treatment for: early breast cancer
Khalil
Based on the case reports and studies performed to date on the retinal toxicity of tamoxifen, retinopathy appears to occur in as many as 12% of patients taking 20 mg tamoxifen a day for over 2 years
038
Its rich blood supply and relatively small mass increase the susceptibility of the eye to drug-related adverse effects
Multiple case reports have long described the retinopathy that tamoxifen can cause crystalline deposits and pseudocystic foveal cavitations, shown in Fig
The standard dose of the drug is 20 mg once a day for 3 to 5 years
Department of Ophthalmology, Tampere University Hospital, Tampere, Finland
Methods: Sixty-five women with breast cancer, on tamoxifen oral therapy (20 mg/day), and a totally normal eye examination, were prospectively followed up