• IV and oral PPI appear to be equally efficacious in suppressing gastric acid
It is indicated for
Proton pump inhibitor (PPI) therapy is indicated in the following clinical situations: Peptic ulcer disease – PPIs are first-line antisecretory therapy in the treatment
with 10 mL of 0
Patients with acute upper gastrointestinal (GI) bleeding commonly present with hematemesis (vomiting of blood or coffee-ground-like material) and/or melena
In the present study, both PPI drug
Proton Pump Inhibitors
Hospital-based uses for oral and intravenous PPI therapies Open in a separate window * Patients with chronic nausea and vomiting or severe diarrhea, such as those
Current guidelines recommend PPI therapy through
If any of these effects last or get worse, tell your doctor or pharmacist promptly Two Minute Infusion
Inspect the diluted pantoprazole sodium for injection solution visually for particular matter and discoloration prior to and during
High-dose PPI regimens (80-mg intravenous bolus followed by a 72-hour continuous intravenous infusion of 8 mg/hr) have been reported to keep gastric pH >6
Parenteral: Initial dose: 80 mg via IV infusion every 12 hours, given over at least 2 minutes OR over 15 minutes
86–1
Compared with intermittent bolus dosing (n = 209), patients receiving continuous infusion PPI (n = 237) were associated with a higher rate of rebleeding (33
Therapeutic class: Proton Pump Inhibitor (PPI) Route of administration: For Intravenous use only
9% NS in a syringe and give IV push or via syringe infuser or in a 50 mL minibag
For patients with high-risk bleeding ulcers who have been treated endoscopically, treatment with intermittent proton pump inhibitor (PPI) therapy is as effective as continuous infusion of PPIs for the prevention of rebleeding
Study objective: To assess the effect of a prolonged continuous infusion of pantoprazole on patient outcomes when the drug was combined with standard octreotide therapy in patients with variceal hemorrhage
Proton Pump Inhibitors
ED decision of intermittent vs continuous PPI should consider other patient factors including severity of illness, compatibility of IV lines (pantoprazole is often incompatible), and patient disposition
Similarly, Wurzer et al
After 72 hours of IV treatment patients should be In these cases, Hospital Consultants may advise stat doses of IV PPI
by slow intravenous injection - give two vials of 40mg, over 2 minutes each
Return the reconstituted vials to the bag to give an 80mg in 100mL infusion solution
The objective of this study is to evaluate clinical outcomes of continuous infusion PPI versus intermittent IV bolus PPI prior to EGD
Safety and efficacy of PROTONIX I
Intravenous pantoprazole is indicated for the treatment of patients who require PPI therapy but who are unable to take oral medication