Furosemide strongly binds to plasma proteins (91–99%) (34), particularly to anionic sites on albumin (20)
Apart from its primary
In heart failure patients, it has been demonstrated that venous capacitance and blood flow in the calf increased within 5 minutes after administration of furosemide
5 to 1
On the other hand, the increased venous capacitance induced by furosemide has been shown to be abolished by nephrectomy”, l3 and inhibited by indomethacin,12
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Furosemide, one of the loop diuretics, disrupts normal cochlear function