A number of countries have authorised the hospital use of hydroxychloroquine or its use in clinical studies under the supervision of healthcare
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Later, large, randomized trials did not confirm it (RECOVERY, SOLIDARITY)
Hydroxychloroquine is a derivative of chloroquine that has both antimalarial and antiinflammatory activities and is now most often used as an antirheumatologic agent in systemic lupus erythematosis and rheumatoid arthritis
In the past, chloroquine was used widely as a prophylactic agent to prevent Plasmodium infection
Our study found no significant differences among hydroxychloroquine, lopinavir-ritonavir, or placebo in COVID-19–associated hospitalizations, time to hospitalization, or time to viral clearance
We performed all searches up to 15 September 2020
2020; 49 The study said hydroxychloroquine “did not significantly improve clinical status at day 14″ among hospitalized patients with respiratory illness from COVID-19
3-9 Hydroxychloroquine was adopted into routine care for hospitalized adults with COVID-19 at many hospitals
The largest of these studies, enrolling over 96,000 patients, initially demonstrated increased in-hospital mortality rates in patients treated with chloroquine or hydroxychloroquine
Hydroxychloroquine is used to treat autoimmune diseases including arthritis