This study provides important information to help simulate the clearances of efavirenz
Efavirenz is predominantly cleared by hepatic metabolism ( Mutlib et al
Apparent EFV clearance after oral administration in fast metabolizers was
Following continued administration of efavirenz, plasma concentrations are lower than
After getting WHO clearance, Thailand’s Government Pharmaceutical
Rifampin Cmax and AUC0-24 hour had no significant relationship with the efavirenz
5 by efavirenz, and systemic clearance and the hepatic extraction ratio
The CYP2B6*6 allele is associated with lower efavirenz clearance
Taking efavirenz emtricitabine, and tenofovir at bedtime may make certain side effects less bothersome
DMD # 51755 4 Abstract Efavirenz is mainly cleared by the cytochrome P450 (CYP) 2B6
The 2 individuals homozygous for multidrug resistance protein 1 3435-T/T had 2
It is generally recommended for use with other antiretrovirals
The current investigation confirms those findings and is the first analysis to quantify the effect of the CYP2B6 516G>T|983T>C SNP vector on efavirenz clearance in African children using nonlinear mixed‐effects modelling
Conclusions: HIV-positive smokers presented with significantly higher efavirenz clearance and unfavourable clinical outcomes
1 to 2
75 to 11 days after dolutegravir
Although multiple CYPs show activity toward this reaction in vitro , this pathway is predominantly catalyzed by CYP2B6 in vitro ( 5 , 25 , 29 ) and probably in vivo ( 15 , 30 )
) Efavirenz/emtricitabine/tenofovir DF (Atripla): Do not use in those with Cl cr <50 mL/minute