Efavirenz clearance

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  • , 2004; Rotger et al
  • The CYP2B6*6 allele is
  • Reduced EFV doses (i
  • presumably because of increased clearance of the drug
  • Dosing: Adult
  • Analyses were repeated within subgroups based on self-identified race
  • This study provides important information to help simulate the clearances of efavirenz

    Efavirenz is predominantly cleared by hepatic metabolism ( Mutlib et al

    Apparent EFV clearance after oral administration in fast metabolizers was

    Following continued administration of efavirenz, plasma concentrations are lower than

    After getting WHO clearance, Thailand’s Government Pharmaceutical

    Rifampin Cmax and AUC0-24 hour had no significant relationship with the efavirenz

    5 by efavirenz, and systemic clearance and the hepatic extraction ratio

    The CYP2B6*6 allele is associated with lower efavirenz clearance

    Taking efavirenz emtricitabine, and tenofovir at bedtime may make certain side effects less bothersome

    DMD # 51755 4 Abstract Efavirenz is mainly cleared by the cytochrome P450 (CYP) 2B6

    The 2 individuals homozygous for multidrug resistance protein 1 3435-T/T had 2

    It is generally recommended for use with other antiretrovirals

    The current investigation confirms those findings and is the first analysis to quantify the effect of the CYP2B6 516G>T|983T>C SNP vector on efavirenz clearance in African children using nonlinear mixed‐effects modelling

    Conclusions: HIV-positive smokers presented with significantly higher efavirenz clearance and unfavourable clinical outcomes

    1 to 2

    75 to 11 days after dolutegravir

    Although multiple CYPs show activity toward this reaction in vitro , this pathway is predominantly catalyzed by CYP2B6 in vitro ( 5 , 25 , 29 ) and probably in vivo ( 15 , 30 )

    ) Efavirenz/emtricitabine/tenofovir DF (Atripla): Do not use in those with Cl cr <50 mL/minute

    The pharmacokinetics of efavirenz have been studied in 71 children with a G to T polymorphism at position 516 of the CYP2B6 gene, which affected its oral clearance [53]

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