Depo-Provera CI can cause serious side effects, including: Use of Depo-Provera CI may cause you to lose calcium stored in your bone and decrease your bone mass
Introduction: Depot medroxyprogesterone acetate (DMPA; Depo-Provera, Tadworth, UK) contraception is used by more than 9 million women worldwide and has a high usage among teenagers in the United Kingdom and the United States
Bone Mineral Density and Fracture Risk Bone mass or BMD refers to the amount of mineral matter per volume of bones and directly correlates with bone strength 6
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• It is unknown if use of Depo-Provera CI during adolescence or early adulthood, a critical period Studies are lacking on how best to prevent and treat medroxyprogesterone acetate-associated bone mineral density loss; however, it may be wise to routinely recommend regular weight-bearing exercise, smoking cessation, and calcium and vitamin D supplementation to women prescribed the drug
Do not use this drug for longer than 2 years unless other options will not work or cannot be used
Depo-Provera is given as an injection every three months
It is not known what the effects will be on Bone Mineral Density Use of parenteral medroxyprogesterone preparations (i
This causes a decrease in bone strength
This reduction of estrogen levels has been shown to reduce bone mass when used over the long term
For example, research demonstrated that use of depot medroxyprogesterone acetate (DMPA) for 2 years results in a 5
(1-4) As a result, the Food and Drug Administration issued a warning in 2004 advising Medroxyprogesterone acetate reduces serum estrogen levels when given as 150 mg intramuscularly every 3 months and is associated with loss of bone mineral density (BMD); this loss of BMD is of particular concern during adolescence and early adulthood, a critical period of bone accretion; unknown, if used by younger women, will reduce peak bone Bone mineral density loss: [US Boxed Warning]: Prolonged use of medroxyprogesterone contraceptive injection may result in a loss of bone mineral density (BMD)
1) • Medroxyprogesterone is a form of progesterone, a female hormone that prevents ovulation (the release of an egg from an ovary)
The benefits of using progestogen-only contraceptives (POCs), such as medroxyprogesterone acetate, should be weighed against the possible risks for each individual woman
Cundy T, Farquhar CM, Cornish J, Reid IR
in 1992, preliminary research indicated that women using it experienced bone mineral density losses that could lead to osteoporosis and fractures
When used correctly, it is as much as 99
It is unknown if use of Depo-Provera during adolescence and early adulthood, a critical period of bone accretion, will reduce peak bone mass
87 percent per year for the Depo-Provera users and a gain of 0
It is unknown if use of Depo-Provera CI during adolescence or early adulthood, a critical period of bone accretion, will reduce peak bone mass You should not use Depo-Provera if you have: undiagnosed vaginal bleeding, liver disease, breast cancer, if you are pregnant, or if you have ever had a stroke or blood clot
It is unknown if use of Depo-Provera CI by younger Introduction: Depot medroxyprogesterone acetate (DMPA; Depo-Provera, Tadworth, UK) contraception is used by more than 9 million women worldwide and has a high usage among teenagers in the United Kingdom and the United States
Several studies have shown that bone density falls a little in women using Depo-Provera
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Bone loss is greater with increasing duration of use and may not be completely reversible
Unlike other commonly used contraceptives, depot medroxyprogesterone acetate decreases pituitary gonadotropin secretion, leading to reduced estrogen production and possibly loss of bone mineral puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
sudden loss of coordination
Depo-Provera contraceptive may increase risk of cardiovascular disease
J Clin Endocrinol Metab
Bone loss is greater with increasing duration of use and may not be completely reversible
It is unknown if use of these contraceptive injections during adolescence or early adulthood, a critical period of bone accretion, will reduce peak bone mass and increase the risk for 5
There are real concerns that Depo may be bad for women's bone health because Depo causes bone loss ( 2, 3 )
The medication should not be used for longer than two years unless absolutely necessary as long-term therapy will increase risk of bone loss
Depo-Provera; Depo-Provera Contraceptive; Depo-SubQ Provera 104; Descriptions
This is because progestin can interfere with the body's ability to absorb calcium, which is essential for maintaining strong bones
Women have reported experiencing adverse effects like bone density loss, menstrual irregularities, and mood changes
"1 "Reversible osteopenia" was mentioned as a possible adverse effect of depot medroxyprogesterone acetate (DMPA, marketed as Depo Provera, Pharmacia & Upjohn, Kalamazoo, MI)
It is unknown if use of depo-subQ provera 104 during adolescence or early adulthood, a critical period of bone accretion, will reduce peak bone mass and increase the risk for Introduction
However, this is usually recovered after stopping the injection and there is no evidence that the progestogen-only injectable increases the risk of fracture
With continued use, the decline in bone density subsequently approaches the normal rate of age-related loss
It has been approved for contraception in the USA since 1992, but has been available in some countries since the 1960s
Which is an important concern during adolescence and/or early
Depo-Provera is used as contraception to prevent pregnancy
Medroxyprogesterone acetate (MPA), also known as depot medroxyprogesterone acetate (DMPA) in injectable form and sold under the brand name Depo-Provera among
Bone Mineral Density Use of parenteral medroxyprogesterone preparations (i
severe, sudden headache
Bone loss is greater the longer the drug is used and may not go back to normal
Medroxyprogesterone is also used to treat changes in sexual interest/ability, swelling of the ankles/feet, bone
Bone density in women receiving depot medroxyprogesterone acetate for contraception [published erratum appears in BMJ 1991 Jul27;303(6796):220]
Short-term effects of high dose oral medroxyprogesterone acetate on bone density in premenopausal women
3 Bone Mineral Density in Women Treated with Depo-medroxyprogesterone acetate for Contraception In a study that compared changes in bone mineral density (BMD) in adult women using depo
Depo Provera pre-vents the ovaries from releasing eggs, causes the Women who use depo-subQ provera 104 may lose significant bone mineral density
Birth control and endometriosis pain: Using this drug for birth control or endometriosis pain may cause bone loss
Bone loss is greater with increasing duration of use and may not be completely reversible
Unlike other commonly used contraceptives, depot medroxyprogesterone acetate decreases pituitary gonadotropin secretion, leading to reduced estrogen production and possibly loss of bone mineral DMPA (Depo-Provera) works by suppressing ovulation and ovarian production of estrogen
Women who use medroxyprogesterone contraceptive may lose significant bone mineral density (BMD)
sudden, unexplained shortness of breath
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, metabolic bone disease, chronic alcohol and/or tobacco use, anorexia nervosa, strong family history of osteoporosis or chronic use of drugs that can reduce bone mass such as anticonvulsants or corticosteroids)
It is unknown if use of Depo-Provera CI by younger Depo is a high-dose synthetic progestin ( progesterone -like chemical) given as an injection every three months ( 1 )
Your doctor will need to see you on a regular basis while you are using medroxyprogesterone
Chemistry
3, 17, 23 A common regimen for a hormonal challenge is 10 mg of medroxyprogesterone Depo-Provera CI can pose an additional risk in patients with risk factors for osteoporosis (e
, metabolic bone disease, chronic alcohol and/or tobacco use, anorexia nervosa, strong family history of osteoporosis or chronic use of drugs that can reduce bone mass such as anticonvulsants or corticosteroids)
This is because progestin can interfere with the body’s ability to absorb calcium, which is essential for maintaining strong bones
Depot medroxyprogesterone acetate