6) Tizanidine hydrochloride may cause hepatocellular liver injury
The CNS depressant effects of Sedation: tizanidine hydrochloride may interfere with everyday activities; sedative effects of tizanidine hydrochloride, alcohol, and other CNS depressants are additive (5
5
Warn patients that they may experience hypotension and to be careful when changing from a lying or sitting to a standing position
Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
Tizanidine hydrochloride may cause hepatocellular liver injury
The effects of tizanidine are greatest on polysynaptic pathways
7)Risk of liver injury: monitor ALTs; discontinue tizanidine if liver injury occurs ()Sedation: Tizanidine may interfere with everyday activities; sedative
Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Dry mouth
1 pmol min −1 mg −1 protein and intrinsic clearance of 17 ml min −1 kg −1
In controlled clinical studies, approximately 5% of patients treated with Tizanidine hydrochloride and Elevated liver enzymes - a phase IV clinical study of FDA data Summary: No or few reports are found
However, if dry mouth continues for more than 2 weeks, check with your medical doctor or dentist
Tizanidine may cause hepatocellular liver injury
Safety and efficacy have not been established