Griseofulvin dose in tinea capitis

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  • 3 mg per kg of body weight per day of ultramicrosize
  • for 2: 6 weeks
  • Treatment involves oral antifungals
  • The cure rates were not statistically significant
  • Ultramicrosize (Gris-Peg tablets): 10 to 15 mg per kg per day; single daily dose or two divided doses (maximum: 750 mg per day) Microsize: $44 ($165) for 300 mL of 125-mg-per-5-mL solution The standard dose for griseofulvin used in trials is generally 10 to 20 mg/kg/d or 125 mg/d in participants weighing 10 to 20 kg; 250 mg/d in those weighing from 20 to 40 kg and 500 mg/d for those over 40 kg

    Tinea capitis: 4 to 6 weeks Tinea corporis: 2 to 4 weeks Tinea unguium (onychomycosis): at least 4 months for fingernails and at least 6 months for Hepatic impairment: Although no specific dose adjustments are required, griseofulvin is contraindicated in severe liver disease as it undergoes hepatic metabolism and may worsen liver function Griseofulvin has long been the standard therapy for tinea capitis and is currently the only antifungal agent labeled by the U

    Twelve weeks of griseofulvin treatment had a Griseofulvin is the initial treatment of choice

    and Microsporum spp

    [1] It is caused primarily by the dermatophyte species Microsporum and Trichophyton

    Method: Twenty four consecutive patients with culture proven tinea capitis were treated randomly with griseofulvin (10 mg/kg/day for 8 weeks) or terbinafine (62

    Mold-like fungi called dermatophytes cause tinea capitis

    24, 31 This is reflected in recent changes to the licensing and availability of antifungal therapies in parts

    Terbinafine 187

    On this basis, the following dosage schedule is suggested: 16 to 27 kg: 125 mg to 187

    Call your doctor at once if

    However if repeat courses or if therapy continued beyond 8 weeks then obtain CBC and LFTs

    Treatment involves oral antifungals

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