It is functionally related to a L-ascorbic acid
Ascorbic acid is an electron donor and acts as a cofactor for fifteen mammalian enzymes
Ascorbic acid is believed to be a part of an antioxidant network (shown below) where it is oxidized to reduce alpha-tocopherol radicals At physiological pH, its reduced form predominates as the monovalent ascorbate anion (AA); when it loses the second proton, it is oxidized to dehydroascorbic acid (DHA) [ 1, 2, 3 ]
Oxidation of ascorbic acid (typically to dehydroascorbic acid) is an electrochemically inert (slow) reaction at common electrode substrates
Here, we show uptake of both AA and DHA by primary cultures of rat brain cortical neurons
Since fruits are rich with metabolizing enzymes IUPAC Standard InChIKey: FFMBBTCDQUJTEG-UHFFFAOYSA-N Copy Chemical structure: This structure is also available as a 2d Mol file; Permanent link for this species
1H NMR and 13C NMR studies show that the principle species of DHA is the bicyclic hydrate, 3,6-anhydro-L-xylo-hexalono-1,4-lactone hydrate
It can also interact with certain medications, such as anticoagulants, and can cause an increase in bleeding
Since fruits are rich with metabolizing enzymes Dehydro-L-(+)-ascorbic acid dimer is used to regenerate ascorbic acid(AA)
Dehydroascorbic acid is the oxidized metabolite that is produced when ascorbic acid interacts with a free radical with two unpaired electrons (particularly peroxide)
Dehydroascorbic acid dimer is an organic heteropentacyclic compound obtained by cyclodimerisation of ascorbic acid
DHA is absorbed from the lumen of the small intestine and reduced to AA, which subsequently circulates in the blood
1021/ja2045925
Ascorbic acid is transported in its oxidized form via GLUT1 across the blood-brain barrier
Due to the multiplicity of antioxidant defense mechanisms in Magnetic resonance spectroscopy (MRS) has been noninvasively used to detect small molecules in tissues in vivo (1-4)
Wash face, hands and any exposed skin thoroughly after handling
Textbooks routinely assign its oxidized form, dehydroascorbic acid, a tricarbonyl structure that is highly improbable in aqueous solution and inconsistent with its colorless appearance
l-Ascorbate, dehydro-l-ascorbic acid (DHA), and 2,3-diketo-l-gulonate (DKG) can all quench reactive oxygen species (ROS) in plants and animals
Neurons were incubated with 1 mM DHA for 30 min, after which PPP activity, assessed as the difference in 14 CO 2 release from [1-14 C]- and [6-14 C]glucose (a) and glucose-6-phosphate dehydrogenase (G6PD) activity (b) were determined
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Vitamin C in its oxidized form as dehydroascorbic acid (DHA) is transported into mitochondria isolated from human kidney cells via GLUT1
A comparison was made between the results obtained with the developed method and a proposed reference method based on Dehydroascorbic acid is an oxidized form of ascorbic acid (Item No
2 It also increases Neuronal injury in ischemic stroke is partly mediated by cytotoxic reactive oxygen species
In addition, vitamin C performs several diverse functions in the Determination of dehydroascorbic acid in biological samples most commonly involves indirect measurement
Ascorbic acid (AA) is a water-soluble vitamin, which plays a significant role in human health [6,7]
Future studies should help to better clarify chemical activity of DHA and related products that form from DHA, as well as to Biological Activity
Molecular Weight
1
The dehydroascorbic acid concentrations measured in supplemented samples agree with known concentrations
L-ascorbic and dehydroascorbic acid are the major dietary forms of vitamin C []
We performed oral loading of AsA or DAsA (1 mmol) in subjects who had consumed a diet low in vitamin C (C) (C< or =5 mg/d) for 3 d before loading, and measured urinary and blood vitamin C
The chemical radical semidehydroascorbic acid also belongs to the group of oxidized ascorbic acids
Three discoveries together point the way to a potential treatment for cancer
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It is trapped therein by reduction back to ascorbate by glutathione and other thiols
Vitamin C is found in foods primarily as ascorbic acid (80-90%), but dehydroascorbic acid (10-20%) is also present
Dehydroascorbic acid is reduced to AA at neutral pH in the presence of thiol-containing reducing agents such as cysteine, homocysteine, 2-mercaptoethanol, and DTT
Molecular Formula C 6 H 6 O 6; Average mass 174
Molecular weight: 636
The fully oxidized form of ascorbic acid, dehydroascorbate, is a bicyclic hemiketal
It is oxidized with loss of one electron
This is
AA acts as an antioxidant and enzyme cofactor
[1- 13 C]DHA has been evaluated as an intracellular redox probe using tumor cells in vitro Product Name L-Dehydroascorbic acid Cat No
Dehydroascorbic acid delay low-density lipoprotein (LDL) oxidation when added before the initiation of the process, they accelerate the process if added to minimally oxidized LDL
It is an organic heteropentacyclic compound, a tetrol and a cyclic hemiketal
Due to the multiplicity of antioxidant defense mechanisms in Magnetic resonance spectroscopy (MRS) has been noninvasively used to detect small molecules in tissues in vivo (1-4)
Call a POISON CENTER or doctor/physician if you feel unwell
Dehydroascorbic acid (DHA) is the oxidized form of the ascorbate, and it has been found that DHA can be reduced reversibly into ascorbate in an enzymatic function and can be stored to increase ascorbate stores in the tissues of guinea pigs; a similar process can be anticipated in humans as well
Many vertebrates can synthesize ascorbate from glucose de novo in the liver
The new compound is
It consists in a spectrophotometric measurement of AA, either directly on the solution added with metaphosphoric acid or after reduction of DHAA into AA by dithiothreitol
doi: 10
Previous work has defined the dehydroascorbic acid (DHA)-GLUT1 transport mechanism by which cells accumulate and retain ascorbic acid (AA) (20–22)
The transported DHA is reduced in the mitochondria
Both molecules are very polar, and cannot be retained by reverse-phase mechanism
Dehydroascorbic acid is an oxidized form of ascorbic acid (Item No
Neuronal injury in ischemic stroke is partly mediated by cytotoxic reactive oxygen species