Cardizem iv administration

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  • Generic name: Diltiazem Hydrochloride 30mg
  • 23 Intravenous Medication Titration in Critical Care Areas
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  • Diltiazem undergoes extensive metabolism in which only 2% to 4% of the unchanged drug appears in the urine

    In a study involving single oral doses of 300 mg of CARDIZEM in six normal volunteers, the average maximum PR prolongation was 14% with no instances of greater than first-degree AV block

    25 mg/kg (max=20 mg) IV bolus over 2 minutes Diltiazem is well absorbed from the gastrointestinal tract and is subject to an extensive first-pass effect, giving an absolute bioavailability (compared to intravenous administration) of about 40%

    These drugs should be used only in hemodynamically stable patients

    25 mg/kg actual body weight as a bolus administered over 2 minutes (20 mg is a reasonable dose for the average patient)

    Tiazac: 120–240 mg daily PO for hypertension—once daily dose; 120–180 mg PO once daily for angina

    Continuous IV infusion: 5–10 mg/hr with increases up to 15 Nursing interventions

    Diltiazem undergoes extensive metabolism in which only 2% to 4% of the unchanged drug appears in the urine

    Patients may respond with a smaller than calculated dosage

    125 mcg/kg/min continuous IV infusion (maximum: 10 mcg/min) for 12 – 24 hours

    In a study involving single oral doses of 300 mg of CARDIZEM in six normal volunteers, the average maximum PR prolongation was 14% with no instances of greater than first-degree AV block

    The kinetic profile of diltiazem, a novel calcium antagonist, was studied in 12 volunteers following oral (60 mg) and intravenous (15 mg) administration

    2 h and an elimination half-life of 3

    , those with Wolff-Parkinson-White or Lown-Ganong-Levine syndrome)

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