Diltiazem undergoes extensive metabolism in which only 2% to 4% of the unchanged drug appears in the urine
In a study involving single oral doses of 300 mg of CARDIZEM in six normal volunteers, the average maximum PR prolongation was 14% with no instances of greater than first-degree AV block
25 mg/kg (max=20 mg) IV bolus over 2 minutes Diltiazem is well absorbed from the gastrointestinal tract and is subject to an extensive first-pass effect, giving an absolute bioavailability (compared to intravenous administration) of about 40%
These drugs should be used only in hemodynamically stable patients
25 mg/kg actual body weight as a bolus administered over 2 minutes (20 mg is a reasonable dose for the average patient)
Tiazac: 120–240 mg daily PO for hypertension—once daily dose; 120–180 mg PO once daily for angina
Continuous IV infusion: 5–10 mg/hr with increases up to 15 Nursing interventions
Diltiazem undergoes extensive metabolism in which only 2% to 4% of the unchanged drug appears in the urine
Patients may respond with a smaller than calculated dosage
125 mcg/kg/min continuous IV infusion (maximum: 10 mcg/min) for 12 – 24 hours
In a study involving single oral doses of 300 mg of CARDIZEM in six normal volunteers, the average maximum PR prolongation was 14% with no instances of greater than first-degree AV block
The kinetic profile of diltiazem, a novel calcium antagonist, was studied in 12 volunteers following oral (60 mg) and intravenous (15 mg) administration
2 h and an elimination half-life of 3
, those with Wolff-Parkinson-White or Lown-Ganong-Levine syndrome)