Fluconazole use in pregnancy has been reported to be associated with spontaneous abortions, congenital heart disease (cardiac septal defects), and
Although treatment with oral fluconazole during pregnancy is generally discouraged, approximately 4% of pregnant women in the United States use fluconazole
Your
Topical drugs are used throughout pregnancy because of limited absorption
99, 95% CI 1
Oral fluconazole
Treatments For Yeast Infection During Pregnancy
Design, setting, and participants: Nationwide register-based cohort study in Denmark, 1997-2013
N Engl J Med 369:830-9
The majority of fluconazole-exposed pregnancies were in women who received common therapeutic doses of 150 mg (56% of pregnancies) or 300 mg (31%)
38–2
VVC occurs frequently during pregnancy
The oral antifungal agents used during pregnancy were fluconazole and itraconazole
However, check with your doctor before using this medicine during the first trimester of
Vaginal candidiasis is common in pregnancy
Can I reassure her? Answer: Short-term and low-dose fluconazole exposure, such as that indicated in the treatment of vaginal candidiasis, is not expected to increase the overall risk of major Only one case–control study reported fetal outcomes following the administration of fluconazole during the first trimester of pregnancy
Not all vaginal creams and suppositories are okay to use during pregnancy, so it is best to consult your doctor or pharmacist to get the right one
Use of oral fluconazole in pregnancy was associated with an increased risk of spontaneous abortion when compared to topical azole use: 130 of 2823 pregnancies vs 118 of 2823 pregnancies, respectively (HR=1
In addition, exposure to fluconazole was significantly associated with an increased risk of spontaneous abortion (OR 1
Maternal exposure to fluconazole during pregnancy has been shown to be associated with an increased risk of spontaneous abortion, and the risk of anomalies of cardiac septal closure among users of high-dose (> 150 mg) fluconazole during the first trimester of pregnancy