Phenytoin zero order

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  • Elimination of drugs
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  • The clearance of phenytoin is non-linear
  • Indications The FDA approved phenytoin in 1939 for the treatment of epilepsy

    Examples of zero order elimination include ethanol, phenytoin and salicylates (at high doses) Basic Science

    First order (linear) kinetics at low concentrations Zero order kinetics at higher concentrations due to saturation of hepatic enzymes Half life variable 12-36 hours Small

    It follows first order kinetics at low blood levels

    Aug 28, 2014 at 21:37 Zero-order kinetics is linear, and the rate of metabolism of a particular drug is constant despite the amount of drug present

    Therapeutic drug monitoring of phenytoin is carried out to ensure effective and safe levels

    There is no oral formulation of fosphenytoin

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