Mechanism of action
is a proton pump inhibitor (PPI) indicated for the: • Short-term treatment of Gastroesophageal Reflux Disease (GERD) with erosive esophagitis (EE) in adults and
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Erosive reflux esophagitis; long-term management of patients w/ healed esophagitis to prevent relapse; symptomatic treatment of GERD
Esomeprazole
Four multicenter, double-blind, randomized trials evaluated the healing rates of Nexium 40 mg, Nexium 20 mg, and omeprazole 20 mg in subjects with endoscopically diagnosed erosive esophagitis
3% for the placebo group
With doses above 80 mg daily, the dose should be Amlodipine is an oral dihydropyridine calcium channel blocker
Proton pump inhibitors (PPIs) are weak bases composed of two moieties, a substituted pyridine with a primary pK a of about 4
Symptomatic treatment of GERD 20 mg once daily
The absolute bioavailability is 64% after a single dose of 40 mg and increases to 89% after repeated once-daily administration
At 30 days post-treatment, the occurrence of rebleeding in the Nexium treated 4
Each delayed-release capsule contains either 10 mg, 20 mg or 40 mg of omeprazole in the form of enteric-coated granules with the following inactive ingredients: cellulose, disodium hydrogen phosphate, hydroxypropyl cellulose, hypromellose, lactose, mannitol, sodium
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Nexium 40 mg tablets are a pink, oblong, biconvex, film-coated tablet engraved 40 mg on one side and A/EI on the other side
Hydrochloric acid (HCl) secretion into the gastric lumen is a process regulated mainly by the H(+)/K(+)-ATPase of the proton pump, Pantoprazole excretion in human milk has been found in a study performed with a single nursing mother after one 40 mg oral dose
Mechanism of action
3) To titrate: start with initial dosage of 10 mg once daily for 7 days, followed by 20 mg once daily
Scientific Name
binds to H+/K+-exchanging ATPase (proton pump) in gastric parietal cells, resulting in blockage of acid secretion
Omeprazole is a proton pump inhibitor (PPI)
Nizatidine is a competitive, reversible inhibitor of histamine at the histamine H2-receptors, particularly those in the gastric parietal cells