Many drugs can trigger this allergic reaction, but antibiotics are the most common group
Rash (10%) Variable appearing rash that is erythematous and blotchy is often found on the torso
2013;13 Suppl 3:41-54; The amoxicillin-induced rash in IM is still a matter of controversy and may be a prelude to a persistent delayed-type hypersensitivity
Amoxicillin and ampicillin should not be used because they may cause a morbilliform rash in patients with infectious mononucleosis
Skin eruption during EB virus infection is characterized by generalized maculopapular, urticarial, or petechial rash involving the palms and soles following administration of amoxicillin or other antibiotics [
The rash doesn't necessarily mean that they're allergic to the antibiotic, however
"Ampicillin rash," a phenomenon unique to patients with Epstein-Barr virus acute infectious mononucleosis (AIM) treated with ampicillin, was first reported in the 1960s
This usually develops a few days after starting amoxicillin
Ampicillin rash, which appears to be unique to ampicillin-treated children with Epstein-Barr virus (EBV)–related acute infectious mononucleosis (AIM), was first reported in the 1960s to have an incidence of 80% to 100%
Severe amoxicillin-induced rash in infectious mononucleosis or in EBV reactivation may be closed to DRESS and fulfil the diagnostic criteria of DRESS [3,4]
Guillain-Barre syndrome
Exanthematous (maculopapular) drug eruption, also called morbilliform (measles-like) drug-induced exanthem, is the most common drug hypersensitivity reaction [ 1,2 ]
Epstein-Barr virus (EBV) causes infectious mononucleosis (IM) with skin rash
headache
In a retrospective Israeli study, 1 173 (72%) of 238 children with positive EBV serology had received antibiotics
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