How can hydroxyurea help with sickle cell disease? Hydroxyurea reduces the problems that sickle cell disease causes
Describe indications for use of hydroxyurea in adults with sickle cell anemia
People who take hydroxyurea must use it regularly as
hydroxyurea, sickle cell anemia, blood transfusion To understand the rationale and processes involved in establishing optimal hydroxyurea dosing
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Hematology, ASH
It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells
Authors' conclusions
Hemoglobin is the protein inside red blood cells that carries oxygen to the body
Homozygous hemoglobin S (HbSS) is the most severe genotype, and The initial trials with hydroxyurea (Phase-III Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH)) demonstrated a clear benefit over placebo in reducing the incidence of pain crises and the cost of care
Hydroxyurea is the primary and most well-established Hydroxyurea is a chemotherapy agent with potent effects on the bone marrow
• Experts strongly recommend hydroxyurea for people with sickle cell disease type SS or type sickle beta zero (Sβ0) Generic Name Hydroxyurea DrugBank Accession Number DB01005 Background
It is associated with lifelong morbidity and a reduced life expectancy
The presence of hydroxyurea in cells primarily activates the S-phase checkpoint, which delays mitosis and arrests the cell cycle progress until DNA replication is finished and any occurring DNA damage is fixed
More research is needed to know if hydroxyurea is safe to take during pregnancy
2010 ) Decreased sperm counts, which did not normalize after hydroxyurea cessation, were noted in one study without a comparator group
Hydroxyurea will not cure sickle cell anemia
These blood cells with the defective hemoglobin are sticky and can build up and block small blood vessels leading to pain and other complications of the disease
Some of the more common side effects of this medication includes
It usually decreases the rate of painful episodes by 50 %