Metabolic fate of chloroquine

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  • More information: Xiaoli Pan et al, Metabolic plasticity of T cell fate decision, Chinese Medical Journal (2023)

    Additional metabolic weaknesses were found in glutathione generation and lipid synthesis during chloroquine treatment

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    Chloroquines consequently have critical effects in tissue metabolic activity and importantly, in key functions of the immune system

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    It is also indicated in other conditions such as autoimmune diseases including rheumatoid arthritis and systemic lupus erythematosus [4–6]; and diabetes [7, 8]

    Chloroquine

    In humans, the antimalarial drug chloroquine (CQ) is metabolized into one major metabolite, N-desethylchloroquine (DCQ)

    Drug resistant strains of the malaria parasite, Plasmodium falciparum, have rendered chloroquine ineffective throughout much of the world

    This variation in signature can be illustrated by the metabolic fate of gallic acid (GA) as it occurs in the free and conjugated form in black tea

    Renewed interest in

    Malaria is a mosquito-transmitted blood infection caused by Plasmodium parasites

    While the downregulation of basal respiration was only observed at 72 h (Fig

    Download scientific diagram | Major metabolic pathways of chloroquine

    Abdel-Gayoum AA, Haider SS, Tash FM, et al

    Plasma concentrations of the principal metabolite, the 4-carboxylic acid derivative, exceed those of mefloquine

    Although chloroquine has an anti-inflammatory activity, when used in association with immune stimulators, the drug may enhance immune responses

    Chloroquine, Hydroxychloroquine, and some of their chemically synthesized derivatives, taken from earlier published studies were selected as drug molecules

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