In SARS-CoV-2 cells, chloroquine suppresses viral entry and
A recent case report showed that treatment with remdesivir improved the clinical
As chloroquine/hydroxychloroquine probably inhibits viral replication by a mechanism different from those of currently used antiretroviral drugs, its application has been studied
—ie, cell culture models in which cellular uptake of chloroquine is closer to the conditions occurring in vivo
The spike glycoprotein is a type I
Glycosylation often affects A, B Human osteosarcoma U2OS cells were treated with chloroquine (CQ), hydroxychloroquine (HCQ), and azithromycin (AZT; all at 10, 20, 40 μM) for 16 h, then fixed and imaged
et al
26−29 Repurposing approved drugs can be an efficient method to identify Hydroxychloroquine for Covid-19 Prophylaxis In this double-blind, randomized trial, 821 asymptomatic persons with a high-risk or moderate-risk exposure to SARS-CoV-2 were assigned to receive The antiviral activity of aminoquinoline‐4 agents is thought to be related to inhibition of virus entry and disruption of viral replication
Chloroquine and hydroxychloroquine impede lysosomal activity and autophagy, leading to a decrease of antigen processing and presentation
Based on existing evidence, the therapeutic approach should include a combination of 1) eradication of the virus by inducing an innate immune response, 2) inhibition of viral replication, 3) destruction of bacteria by antibiotic regiments, and 4) clearance of inflammation and inflammatory precursors without affecting the host' cell cell
CQ/HCQ could inhibit viral entry by acting as inhibitors of the biosynthesis of sialic acids, critical actors of virus-cell ligand recognition
Its antibacterial and antiviral effects are attributed to the alkalinization of intracellular acidic organelles infected by bacteria and to the inhibition of entry steps and viral proteins glycosylation []
The majority of these studies have revealed a substantial ability of CQ and HCQ as well as some of their derivatives to inhibit viral replication with no to low toxicity
D
Hydroxychloroquine could cause fatal heart rhythm problems, especially if you take it with another drug
NLRP3 inflammasome has been shown to play a key role in the pathogenesis of viral diseases