Adults
The starting dose of clonidine hydrochloride injection should be selected on per kilogram basis (0
1 mg per day may be made at weekly intervals if necessary until the desired response is achieved
1 mg per day for one week), 8
Due to the lack of controlled clinical trial data and differing pharmacokinetic profiles, substitution of extended-release clonidine for other clonidine products on a mg-per-mg basis is not recommended
Given once or twice a day
Fertility of male or female rats was unaffected by clonidine doses as high as 150 mcg/kg (approximately 3 times MRDHD)
DOSAGE AND ADMINISTRATION Adults
1 mg/kg/dose q2-4h PRN or NCA boluses for pain
5% bupivacaine 19 ml with clonidine 150 mcg/kg given every 48 hours for 3 weeks via an indwelling catheter 29
0
Fertility of male or female rats was unaffected by clonidine doses as high as 150 µg/kg (approximately 3 times MRDHD)
Depending on units selected, the general composition for the formula is as follows: IV Drip Rate (mL/hour) = (60min/hr * (Desired Dose in mcg/kg/min) * (Weight in kg)* (Bag Volume in mL) / (1000 mcg/mg) * (Drug in Bag in mg In mice and rats, the oral LD 50 of clonidine is 206 and 465 mg/kg, respectively
1 mg per day may be made at weekly intervals if necessary until the desired Do not stop suddenly (esp
1 mg per day may be made at weekly intervals if necessary until the desired response is achieved
5–1 microgram/kg 3 times a day, then increased if necessary up to 25 micrograms/kg daily in divided doses, increase dose gradually; maximum 1
per dose 300 micrograms) for 1 dose
1 mg, or zopiclone 7
In a separate experiment, Maintenance Dose: Further increments of 0
was observed in males treated with the combination treatment of 300 mcg/kg/day clonidine
Behavioral modification: 0
3 cm 2 (0
In mice and rats, the oral LD 50 of clonidine is 206 and 465
Most veterinarians start their canine patients on the lowest effective dose and incrementally increase the dosage as needed