100–400 mg per day, taken in 1 or 2 divided doses
Adults taking valproic acid (Depakote®)—At first, 25 mg of lamotrigine once every other day for 2 weeks, then 25
Recommended dosage*
The decrease in dose of LAMICTAL should not exceed 25% of the total daily dose per week over a 2-week in patients treated for acute mood episodes with
Note: If valproate is discontinued, increase daily lamotrigine dose in 50 mg increments at weekly intervals until dosage of 200 mg/day is attained
(2
02/22/2024 12:44 p
2) • Conversion to monotherapy: T arget therapeutic dosage range is 250 to 300 mg daily
, achieving a 50% reduction in the daily dosage of lamotrigine each week) unless safety concerns require more rapid withdrawal
Weeks 1 and 2
Weeks 3 and 4: 100 mg/day in divided doses Increasing the lamotrigine dose to 50 mg/day yielded more substantial symptomatic relief such that flashbacks and nightmares ceased within 3 weeks of lamotrigine augmentation
You may be more likely to develop a serious rash if you take a higher starting dose or increase your dose faster than your doctor tells you that you should
Teva-lamoTRIgine
The effects of lamotrigine last for over 24 hours, and once-daily dosing is often prescribed
Usual maintenance: 225-375 mg daily in 2 divided doses
(5
by 50 mg/day q1-2wk; Max: 375 mg/day; Info: dose adjustment may be needed during pregnancy and/or postpartum; taper dose over 2wk to D/C
Adjunctive Therapy
3 )]
) dosage regimen of < or = 700 mg/day lamotrigine (LTG) and to include determination of the LTG pharmacokinetic profile at doses > or = 500 mg/day in patients receiving concomitant enzyme-inducing antiepileptic drugs (AEDs)
Common side effects of lamotrigine that are not Lamotrigine is usually taken 1 or 2 times daily with or without food
Lamotrigine is available as a tablet to be taken by mouth one to three times a day