Erythromycin is a macrolide antibiotic initially discovered in 1952
This work demonstrates the synthesis of a pH-cleavable, erythromycin conjugate that retains the inherent antimicrobial activity of erythromycin, has an increased hydrophobicity, and improved Erythromycin, first introduced for clinical use 30 years ago, was found to be effective for the treatment of gram-positive bacterial infections
aureus) infections and is a common alternative
Erythromycin is used to treat certain infections caused by bacteria, such as infections of the respiratory tract, including bronchitis, pneumonia, Legionnaires' disease (a type of lung
Erythromycin esterases (Eres) cleave the macrolactone ring of macrolides, a class of widely used antibiotics
93 kcal/mol
The coconut is termed the “Tree of life” due to all parts of the coconut tree have economic value and benefits
The fibers inside the gel-like phase were confirmed to be new types of EES
Erythromycin binds with a stoichiometry of 1:1 to each monomer of the functional MphR(A) dimer in a large hydrophobic cavern composed of residues from an α‐helix of one monomer and the dimeric interface of the other monomer that appears too close around the ligand as it binds (Zheng et al
Because of the criteria used for identifying the EreC-erythromycin complex model, the putative hydrolysing water
erythromycin stearate will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism
Glaxoderm® (Glaxo) is a hydrophilic creme basis which is available to pharmacies and into which erythromycin, or other drugs, can be incorporated
The evolution of Bordetella pertussis has selected for mutations of acr that lead to sensitivity to hydrophobic molecules and
Packaging: Package in tubes or in push-up ointment containers
Methods and Results: Fifty-one nonrepeat gram-negative bacterial pathogens of various genera, resistant to multiple antibiotics, including
It is useful for treating various infections and also has an indication for a non-infectious pathology
abnormal liver function tests
35 As erythromycin is a hydrophobic molecule, the mexAB-oprM system could facilitate the excretion of this molecule by the efflux pump
Patients infected with inducible resistance phenotypes may fail to respond to clindamycin
The adsorption