Multivariate logistic regression analysis showed that the use of HCTZ, female sex, and baseline uric acid levels strongly predicted the incidence of new-onset diabetes mellitus in hypertensive patients
27424996 Thiazide diuretics are still widely used as an initial therapy in essential hypertension, sometimes in both hypertensive and diabetic patients
These metabolic studies of potassium provide evidence for the effect of hypokalemia on glucose intolerance
Changes in sympathetic nervous
However, hyperuricemia did emerge as a relatively important risk factor for impaired glucose metabolism and new onset diabetes ( 7 )
characterized by AVP
8% and 8
If progressive renal impairment becomes evident, consider withholding or discontinuing
increase her consumption of sodium Methods: This randomized, double-blind, parallel comparison, noninferiority clinical trial included patients with type 2 diabetes mellitus and hypertension and microalbuminuria detected within the past year
It is well accepted that a low to medium dose of a diuretic such as HCTZ (12
The antihypertensive effects of the drug may be enhanced in the post-sympathectomy patient
Hypersensitivity: Sensitivity reactions to thiazides may occur in patients with or without a history of allergy or Background The landmark Antihypertensive and Lipid-Lowering treatment to prevent Heart Attack Trial (ALLHAT) placed a new spotlight on thiazide diuretics as the first-line therapy for hypertension
15
What condition should the nurse monitor for in this client after administering the prescribed drug? A 49-year-old client reports frequent muscle cramps while on hydrochlorothiazide therapy
Aldosterone causes cardiovascular injury and is not suppressed by chronic angiotensin converting enzyme Approximately 23
Renal Impairment
Use with caution in diabetes mellitus, fluid or electrolyte imbalance, hypercholesterolemia, hyperuricemia or gout, hypercalcemia, hypotension, systemic lupus erythematosus, liver or renal disease, hypokalemia, parathyroid disease Irbesartan is an angiotensin II receptor blocker (ARB)
Hydrochlorothiazide, USP is a white, or practically white, crystalline powder which is slightly soluble in water, freely soluble in sodium hydroxide solution, in n-butylamine, and in dimethylformamide; sparingly soluble in methanol; insoluble in ether, in chloroform, and in dilute mineral acids
Some adverse effects associated with hydrochlorothiazide, including increased risk for new-onset diabetes mellitus, may be offset by losartan
decrease her insulin dose
No studies have shown that the progression of microalbuminuria to normoalbuminuria in subjects with diabetes mellitus type 1 can be stopped