Amongst adults patients with an increased risk of GI bleeding requiring emergency ICU admission, pantoprazole is associated with a lower rate of GI bleeding but with higher rates of nosocomial infections and MI than placebo
Krag et al
3%) had died in the pantoprazole group as compared with 601 of 1626 (37
6 issue)¹ showed no significant difference in 90-day mortality between the pantoprazole group and the
/ Pantoprazole in ICU patients at risk for gastrointestinal bleeding-1-year mortality in the SUP-ICU trial
Pantoprazole in patients at risk for gastrointestinal bleeding in the ICU
379, No
Pantoprazole in patients at risk for gastrointestinal bleeding in the ICU
N Engl J Med 2018; 379;
Protocol for: Krag M, Marker S, Perner A, et al
6 issue)1 showed no significant difference in 90-day mortality between the pantoprazole group and the placebo group among patients in the int Pantoprazole IV at various doses vs Cimetidine 300 mg bolus then 50 mg/h infusion: Kantorova: M Krag, S Marker, A Perner, et al
21
N Engl J Med
57 , 3189 Marker S, Krag M, Perner A, Wetterslev J, Lange T, Wise MP et al (2019) Pantoprazole in ICU patients at risk for gastrointestinal bleeding-1-year mortality in the SUP-ICU trial
Intermittent intravenous pantoprazole and continuous cimetidine infusion: Effect on gastric pH control in critically ill patients at risk of developing Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU
In ICU patients at risk of gastrointestinal (GI) bleeding does the use of prophylactic proton-pump inhibitor (PPI) compared to placebo reduce mortality at 90 days? Background Krag M, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S, McArthur C, Cook D, Nielsen N, Pelosi P, Keus F, Guttormsen AB, Moller AD, Møller MH, SUP-ICU co-authors Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients
" New England Journal of Medicine 379
Stress ulcer prophylaxis in the intensive care unit: an international survey of 97 units in 11 countries
Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult S
orgDecember 6, 2018 2201 Pantoprazole in Patients at Risk for Bleeding mechanical ventilation (expected to last >24 hours), any history of liver disease, or any history of or BACKGROUND
Krag M, Perner A, Wetterslev J, et al
Krag M, Marker S, Perner A, et al
Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: systematic review and network meta-analysis
Crit Care Med