Patients with Renal Impairment: In patients with kidney failure, it is generally recommended that metoclopramide maintenance doses be reduced to avoid drug
The pharmacokinetics of metoclopramide have been studied after intravenous and oral dosing (10 mg) to 6 patients with chronic renal failure
Safety and efficacy
This may raise your risk of kidney problems, digestion problems, and tingling (pins and needles) feeling caused by damage to clearance of metoclopramide in renal failure is approximately 30% of norrnals
Limited information
Total body clearance after i
It works by increasing the movements or contractions of the stomach and intestines
Conclusion: Metoclopramide is as effective as tenoxicam to treat pain and nausea for patients with renal colic in the emergency department
Limited information is available on metoclopramide dosing in renal failure
Delayed initiation of dialysis (when Metoclopramide can be used in combination with oral analgesics to improve the absorption of analgesics in acute migraine
" Eur J Clin Pharmacol 19 (1981): 437-41 Other precautions relevant to the elderly when prescribing metoclopramide include Parkinson’s disease, high blood pressure, kidney problems, liver problems, heart failure, and diabetes
Avoid in cardiac failure
9 h after Metoclopramide reduces renal blood flow which may exacerbate pre-existing renal disease
Phenothiazines may potentiate the extrapyramidal side effects of metoclopramide
Metoclopramide in a patient with renal failure may be an increased risk of neuroleptic malignant syndrome Intensive Care Med
Metoclopramide has been linked to rare instances of clinically apparent liver injury that are typically cholestatic and can be associated with bile duct loss
CHF
Elderly Metoclopramide can be prescribed in the veterinary field to treat gastrointestinal muscle stimulation in dogs, cats, horses, rabbits, and other small mammals
cerebral irritation
69)
The NKF Helpline is available Monday to Thursday 08:30am - 5:00pm Friday 08
There is data in healthy male volunteers to show that metoclopramide actually shortens the QT interval while at the same time increasing QT