Because the elimination half-life of thyroxine is approximately 7 days, it is plausible to administer once weekly thyroxine therapy in order to restore euthyroidism
DOI: 10
Maintenance dose: 50 to 100 mcg IV once a day until patient can tolerate oral therapy
Given the need for prompt alternative control, we sought advice from international experts where intramuscular levothyroxine was recommended
She received a supervised total weekly dose of 1150 μg of Synthroid for the first 2 weeks
Twice-weekly administration rather than once-weekly administration (as advised by some 28,31,32) was chosen to reduce the likelihood of fluctuations in T4 levels in the body
It usually is taken once a day on an empty stomach, 30 minutes to 1 hour before breakfast
For adults aged 50 years and over, with cardiovascular disease, or severe Synthroid
Initially 25–50 micrograms once daily; adjusted in steps of 25 micrograms every 4 weeks, adjusted according to response; maintenance 50–200 micrograms once daily, dose to be taken preferably 30–60 minutes before breakfast, caffeine-containing liquids (e
, every 6–12 months)
In view of the long half-life, dose changes should only be made every 3–4 weeks
It is used to treat thyroid hormone deficiency (hypothyroidism), including a severe form known as myxedema coma
Increase the daily dose by 25 to 50 micrograms according to response at not less than 4-weekly intervals, up to 100 to 200 micrograms daily
Replacement therapy with subcutaneous thyroxin injection was continued with 500 μg on
There are several recommended conversions ranging from 50 to 80% of the oral dose but the American Association of Clinical Endocrinologists/American Thyroid Association guidelines recommend an intravenous dose 50-70% of the patient’s oral dose
Once weekly administration of levothyroxine is safe and efficient and therefore a possible alternative
An initial intravenous loading dose of Levothyroxine Sodium for Injection between 300 to 500 mcg followed by once daily intravenous maintenance doses between 50 and 100 mcg should be administered, as clinically indicated, until the patient can tolerate oral therapy
This study aims to establish twice or thrice weekly L-T4