coli expressing the D-desosamine pathway: (a) MegCIV, MegCV, MegDII, MegDIII, MegCIII and ErmE; (b) MegCIV, MegCV, MegDII, MegDIII Erythromycin is a macrolide antimicrobial chemically comprised of a 14-membered lactone ring substituted with a neutral (cladinose) and an amino (desosamine) sugar
124–126 In Streptomyces venezuelae, the aminosugar is biosynthesized as TDP-d-desosamine (91), which is activated for
As with other macrolides, erythromycin inhibits RNA-dependent protein synthesis by reversibly binding to the 50 S ribosomal subunits of susceptible
Desosamine is essential for the bactericidal activity of many of these antibiotics, including erythromycin and many
Structural modifications on erythromycin were carried out at positions 3, 6, 9, 11, and 12 of the 14-membered lactone ring; as In Streptomyces antibioticus, the endogenous antibiotic oleandomycin is inactivated by two family 1 (GT-1; defined in ref
Acid salts of desosamine’s dimethylamino group have
LC/MS/MS analysis of the dTDP-sugar intermediates produced by operons containing different sets of genes showed that production of dTDP-d-desosamine from dtdp-4-keto
The macrolide ring is the lactone (cyclic ester) at upper left
The macrolide antibiotic erythromycin is produced by Saccharopolyspora erythraea
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