To take with food, you may mix the pellets with a non-acidic soft food (pudding, chocolate syrup, mashed potato, ice cream) that is at room temperature
How should this medicine be used?
5-2 hr (sofosbuvir); 2-4 hr (metabolite GS-331007) AUC when coadministered with ribavirin (with or without peg-interferon): 828 ng•hr/mL (sofosbuvir);
1 INTRODUCTION Go to: 1
Sofosbuvir is an FDA-approved antiviral prescription medicine for the treatment of chronic hepatitis C virus infection (HCV)
EPCLUSA is a prescription medicine used to treat
If the oral pellets are taken with food, sprinkle the pellets on 1 or more spoonfuls of non-acidic soft food (eg
If you take this medicine with food, shake the packet gently to settle the pellets to the bottom of packet
Medications such as rifampin (Rifadin), carbamazepine (Tegretol), and herbal supplements like St
The most common side effects reported with this drug were fatigue, headache, nausea, and nasopharyngitis
GS-461203 inhibits RNA-dependent RNA polymerase activity by competing with uridine and prevents HCV RNA
The recommended dose in adults is one tablet (containing 400 mg sofosbuvir and 100 mg velpatasivir) taken once a day for 12 weeks
It works as an inhibitor of the HCV NS5B RNA-dependent RNA polymerase, which acts as a chain terminator
NICE TA330
This combination fills an important role as a pangenotypic regimen for persons who have experienced treatment failure with DAA therapy and has emerged as the first-line salvage option for retreatment
lightheadedness, dizziness, or fainting
These side effects may go away during treatment as your body adjusts to the medicine
trouble breathing
Mechanism of Action: Sofosbuvir is a nucleotide analogue inhibitor, effective against hepatitis C virus (HCV) nonstructural 5B (NS5B) polymerase, which is necessary for viral replication
Several trials are evaluating the use of SOF with other oral DAAs that will provide additional all-oral interferon-free treatment regimens for genotype 1 infections
After 18 hours or more, the dose should be skipped, and the next dose taken at the usual time
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Accordingly, the development of nucleoside inhibitors specific to dengue viral polymerase that perturb dengue infection has been studied by many
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