In patients with adenotonsillar surgery prevention of nausea and vomiting with ondansetron may mask occult bleeding
Serious side effects are rare, but can include serotonin syndrome and heart rhythm problems
Ondansetron, also a 5-HT3RA, has been widely used as an antiemetic with an excellent safety record for over two decades
Moderate-to-severe hepatic impairment — decreased clearance
Ondansetron is a selective 5-HT3 receptor antagonist
• Commonly occurs with
Prescribe anti-emetics regularly
As ondansetron is known to increase large bowel transit time, patients with signs of subacute intestinal obstruction should be monitored following administration
We reviewed the WHO database of adverse drug effects and identified 33 cases of intestinal obstruction or ileus where ondansetron was the only drug involved, as well as 32 cases where in addition to
Mechanism of action
Ondansetron is a specific 5HT 3-receptor antagonist which blocks 5HT 3 receptors in the gastro-intestinal tract and in the CNS
Ondansetron is not a drug that stimulates gastric or intestinal peristalsis
Anti-emetics can be a useful for emesis and/or nausea in cases where surgery is contraindicated (ondansetron 4mg IV q8H prn) Consider NG tube for gastric
On a few occasions, cases have been fatal
People with heart problems involving the conduction of the electrical signals in the heart, such as a slow heartbeat, sick sinus As ondansetron is known to increase large bowel transit time, patients with signs of subacute intestinal obstruction should be monitored following administration
Instruct patients to immediately report any signs or symptoms consistent with a potential bowel obstruction to their healthcare provider [see Warnings
Stevens-Johnson syndrome has been reported in patients with multiple comorbidities
Ondansetron is a selective As ondansetron is known to increase large bowel transit time, patients with signs of subacute intestinal obstruction should be monitored following administration
• Malignant bowel obstruction (MBO) is due to mechanical obstruction (partial or complete) of the bowel lumen and/or peristaltic failure
She started receiving oral ondansetron 4-8 mg/day for 3 months prior to her hospitalisation
Most of the time, complete blockages require a stay in the hospital and possibly surgery
A 29 years old woman, at 21 weeks of gestation experienced extreme abdominal pain that was worsened within half an hour