PPROM 24-32 weeks
Following the destruction of pharmaceutical production facilities in Puerto Rico by Hurricane Maria in September 2017, a shortage of small-volume bags of sterile
The mean length of latency in women with preterm prelabor rupture of membranes was similar between
There is evidence that azithromycin may be an alternative or adjunct to first-generation cephalosporins Adding 500 mg azithromycin, infused over 1 hour, ‘may be
We identified articles between January 1990 and 13 th June 2021 by searching five electronic databases
Despite rupture of membranes
The azithromycin group had azithromycin 1 g orally once daily and ampicillin 2 g every 6 h IV for 48 h, followed by 5 days of amoxicillin 250 mg every 8 h orally
Administration of azithromycin 500mg has been shown to reduce a composite outcome of endometritis, wound infection or other infection (3)
PPROM is largely a clinical diagnosis, which should be based on a combination of the history, physical examination, and select laboratory markers ()
It is Erythromycin* (250 mg IV every 6 hours) Azithromycin (1 gram PO) OR Erythromycin Mean length of latency in women with PPROM was similar between individuals treated with erythromycin and azithromycin
Many institutions have advocated for the use of azithromycin instead of erythromycin
19
The most appropriate antibiotic therapy for PPROM was a combination of 1 g azithromycin given orally on admission plus a third
45 to 0
5 Intravenous erythromycin and ampicillin for two days followed by oral erythromycin and amoxicillin for ve days is the most common regimen used in PPROM that is supported by the ACOG
erythromycin