Allopurinol and renal fialure

Anabel gomez lopes
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    Traditionally

    To the Editor: The uric acid hypothesis proposes that hyperuricemia or gout increases the risk of progression of chronic kidney disease and is based on The dose of allopurinol can be safely increased beyond the CrCl-based dose in patients with kidney disease; allopurinol can be used in patients receiving hemodialysis or peritoneal dialysis who still require ULT, as detailed in Table 1

    1 These observations were supported as potentially causal by experimental models that demonstrated that hyperuricemia caused kidney disease in

    Repeated flares of gout cause joint damage as well as significant health care utilization and decreased quality of life

    Introduction

    Kidney failure is found, especially among people who are male, 60+ old, have been taking the drug for < 1 month, also take Nexium and have Gastroesophageal reflux disease

    USES: Allopurinol is used to treat gout and certain types of kidney stones

    The aim of this study was to evaluate the effect of allopurinol on chronic kidney disease progression

    Since allopurinol and its metabolites are primarily eliminated only by the kidney, accumulation of the drug can occur in renal failure, and the dose of allopurinol tablets USP should consequently be reduced

    Lowering UA with allopurinol may delay CKD progression

    Background: Hyperuricemia is an independent risk factor for diabetic kidney disease (DKD) progression

    Gout happens when uric acid, a normal body waste, gets too high in the blood

    Rats received adenine oral gavage and were treated with either CM (33 mL/kg) or allopurinol (50 mg/kg) for ten consecutive days

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