Chloroquine hemolytic transfusion

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  • Shirley et al
  • 7 kb deletions
  • Reactions occurred in three of six subsequent transfusions
  • 1 Initial ICU laboratory results demonstrated
  • PMCID: PMC9256513
  • It is in the sulfonamides class of drugs
  • 3 hours 4
  • manipulating pH, use of organic solvents, and chloroquine
  • Literature review current through: Dec 2023

    Chloroquine inhibits pro inflammatory cytokine secretion induced by heme on macrophages

    Abstract Chloroquine diphosphate (CDP) is a helpful tool in the blood bank for two main applications

    Introduction

    Delayed hemolytic transfusion reactions (DHTRs) in patients with sickle cell disease are underappreciated and potentially fatal

    Since sensitized K 0 patients are rare, little is known about anti-Ku clinical relevance and in particular about its association to hemolytic disease of the fetus and newborn

    A milder reaction is caused by anti-k, anti-Kp a, anti-Kp b, anti-Js a, and anti-Js b

    Kidney disease or Liver disease—Use with caution

    Chloroquine treatment for identification of Human Leucocyte Antigen (HLA) antibodies could not be done, which is the drawback of the study

    The extent of hemolysis, and therefore the

    The annual incidence of AIHA range from 1 to 3 in 100,000 to 1 in 25,000 individuals

    Generally, most immunohematologists consider re-activity of HLA Other complications include

    Post-transfusion purpura

    The rationale supporting this practice is that replacement of blood loss should be beneficial for the patient

    Hemolytic Transfusion Reactions

    On reviewing the medical history of the patient, the nurse finds that the patient is also receiving digoxin

    Iberis amara 3

    Delayed hemolytic reaction

    This is the most symptomatic complication of blood transfusion

    These studies showed that antibody removal was much more efficient at 30 degrees C and 37 degrees C than at 18 degrees C or 25 degrees C

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  • Chloroquine hemolytic transfusion
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