Nature Communications - Tumour-associated macrophages (TAMs) display an M2 phenotype that promote tumour immune escape
Abstract—To investigate the effects of chloroquine diphosphate (CQ) on lung cancer
The yin and yang of chloroquine and its analogs in fighting COVID-19 Go to: Clinical evidence Two clinical studies from China and France have shown that
Neuronal cell death following chloroquine-induced impairment of autophagic clearance did not require caspase activity, as indicated by the lack of a significant effect
Bioorg Med Chem
Considerations Although chloroquine may be a potential drug for the treatment of COVID-19, randomized controlled trials with large-scale patient populations are needed to ensure its safety and benefits in the treatment of SARS-CoV-2 infection
The results showed that, at lower concentrations (from 0
Appearance: Liang X, Tang J, Liang Y, et al
The novel finding of the present study is that chloroquine is a zinc ionophore, which contributes to our understanding of chloroquine's biological activity in human cancer cells
, we found more punctate patterns of microtubule-associated protein LC3 immunoreactivity in radiation-treated U87 GICs
Cell Death Differ 16 (8): 1093–1107
It inhibits autophagy in a variety of cell lines, induces cell death in breast cancer cell lines, and displays antitumor and antimetastatic activity in mouse models of breast cancer
We provide (±)-Chloroquine diphosphate safety data sheet view and download for free at Echemi
Catalog No
An annexin V/PI assay indicated that although chloroquine did not affect cell viability, VNP20009 lead B16F10 cell death in a time- and dose-dependent manner after pre-inhibition of autophagy To make ~20 mL 25 mM chloroquine in PBS, weigh ~250 mg chloroquine diphosphate salt in a 50 mL tube
Chloroquine diphosphate is the oral form of the drug, and chloroquine hydrochloride is the form used intramuscularly for arrested autophagy, and cell death by chloroquine in cultured ARPE-19 cells
The cells were fixed with 100% methanol (5 min) then permeabilized with 0
This accumulation leads to inhibition of lysosomal enzymes that require an acidic pH, and prevents fusion of endosomes and lysosomes
Cell Research 30:269â 271 Chloroquine, sold under trade names such as Aralen, Avloclor among others, is an aminoquinoline that has antimalarial and anticancer activities
However, it has become a widely used inhibitor for studying autophagy and the role of endosomal acidification in cellular processes, such as in intracellular TLR9 signaling