From 2007 to 2014, there was a nearly 50% decrease in digoxin prescriptions dispensed among older adults
heart failure), the prescribing of digoxin in older patients is inevitably going to increase
7% (95% CI, 18
Digoxin is a medication used to manage and treat heart failure and certain arrhythmias, and abortion
Digoxin, commonly used to treat heart failure,1,2 has a narrow therapeutic range and is eliminated primarily by the kidney
Estimated glomerular filtration rate is widely used to adjust
13) Although we excluded patients with a
27 Findings from the Digitalis Investigation Group recommended a lower plasma concentration compared with previous Objective: To resume the available literature about digoxin population pharmacokinetic studies in elderly patients
The usual amount of digoxin injection that a 70 kg patient requires to achieve 8 to 12 mcg/kg peak body stores is 600 to 1000 mcg
73 m 2 (risk of digoxin toxicity if plasma levels not measured) See also Prescribing in the elderly
[ 58 ] Once differences in patient characteristics have been accounted for, it is unclear whether digoxin has a clear independent association with
Digoxin is a cardiac glycoside that is widely prescribed for the treatment of congestive heart failure (CHF) and atrial fibrillation (AF)
Digoxin may be adequate as monotherapy for ventricular rate control in patients with chronic AF, particularly in sedentary and elderly
The main indications for digoxin usage include atrial fibrillation and heart failure; both these conditions are more prevalent in older patients
Breast Feeding Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding
Arch Intern Med 1991; 151:2194
Further clinical studies are needed to confirm the pharmacokinetic parameters of digoxin in elderly patients with heart failure and/or atrial fibrillation
Digoxin should be avoided or used with extreme caution in the very elderly or in patients with severe conduction abnormalities, acute coronary syndromes, or renal failure
In this article, and unlike the other ones reviewed, the authors established as inclusion criteria patients with oral digoxin for more than 7 days and without serious hepatic or renal dysfunction
Monitor creatinine clearance
Therefore, providers are The trial population comprised primarily male patients, with only 22
32 It is generally agreed that digoxin should be Background Digoxin is a cardiac glycoside that was introduced to cardiovascular medicine more than 200 years ago
The data of 142 elderly patients and 448 samples were collected after repetitive oral digoxin
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