Nonsteroidal anti-inflammatory drugs (NSAIDs) — NSAIDs may increase the risk of gastrointestinal bleeding and ulceration when they are given with corticosteroids
When combined with 5-HT3 antagonists there are reduced serotonin concentrations in the gut and increased sensitivity of 5-HT3 receptors to antiemetics
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The risk factors for gastrointestinal adverse effects with oral corticosteroids include: Concomitant use of drugs that are known to increase the risk of gastrointestinal bleeding, such as nonsteroidal anti-inflammatory drugs (for example aspirin and ibuprofen) and anticoagulants
Adequate intravenous access is essential in the context of upper gastrointestinal bleeding as patients can rapidly deteriorate with haemodynamic
Indeed, the risk of upper gastrointestinal bleeding in NSAID users has been shown to be approximately 4-fold higher than in people not taking NSAIDs [] with an annual event rate per 1,000 persons
10 These complications generally include bleeding gastric and/or duodenal ulcers, and to a lesser extent obstructions and/or perforations
For patients who have either current upper GI bleeding or a history of bleeding ulcers and who require a NSAID, the recommendation is to use a PPI together with a COX-2 inhibitor rather than to use COX-2 inhibitors alone to reduce the risk of recurring bleeding
Approach to acute upper gastrointestinal bleeding in adults; Approach to refractory gastroesophageal reflux disease in adults; Clinical manifestations and diagnosis of acute interstitial nephritis; Clopidogrel resistance and clopidogrel treatment failure; Clostridioides difficile infection in adults: Epidemiology, microbiology, and pathophysiology Some examples of corticosteroids are dexamethasone and methylprednisolone
These common side effects of dexamethasone happen in more than 1 in 100 people
Talk to your doctor or a pharmacist if the advice on how to cope does not help and a side effect is still bothering you or does not go away
Rapid assessment, stabilization, and resuscitation should precede all diagnostic modalities in unstable children
Gastrointestinal (GI) bleeding is a sign of a disorder in the digestive tract
Corticosteroid users on concurrent NSAID therapy or others at higher risk of ulcers or gastrointestinal (GI) bleeding, including those with a history of ulcers or GI bleeding and those with severe comorbidities (e
Dexamethasone sodium phosphate injection was subsequently changed to oral dexamethasone DITP often exhibits severe thrombocytopenia, and it may sometimes induce severe symptoms such as gastrointestinal bleeding and alveolar bleeding, so an early diagnosis is important
Although more than 75% of patients have