They work by preventing specific blood cells (platelets) from clumping together
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Talk to your doctor before using clopidogrel together with pantoprazole
Antiretrovirals: Clinical Impact: Effect Of Pantoprazole On Other Drugs
Design: The present study was performed to evaluate whether combination therapy of clopidogrel and PPIs is associated with increased risk of MACEs than with The increase of VASP-PRI was not significant when treated with pantoprazole, leading the authors to conclude that the clopidogrel-PPI interaction was not a class effect, whereas the combination with pantoprazole was a more optimal treatment option
Talk to your doctor before using clopidogrel together with pantoprazole
People should not take certain PPIs and Plavix or other clopidogrel drugs at the same time
It is created by eHealthMe based on reports from the FDA, and is updated regularly
However, studies have found decreased efficacy of clopidogrel when concurrently administered with a PPI
serum sodium144
Inhibition of platelet aggregation by clopidogrel is entirely due to the active clopidogrel metabolite
It is also a type of antiplatelet medicine
Plavix (Clopidogrel) According to the FDA, medical conditions and diseases that are known to have a negative interaction with pantoprazole include: Gastric malignancy (stomach tumors) Osteoporosis-related bone fractures; Vitamin B-12 deficiency (cyanocobalamin) Clopidogrel (Plavix ®) is a drug used to decrease platelet functioning to prevent undesired arterial blood clots
Omeprazole has inhibitory effects and is metabolized by CYP450 2C19, therefore, potentially limiting the active form of clopidogrel and its antiplatelet effects
Thus, the results of this trial demonstrate the lack of interaction between either pantoprazole or esomeprazole and clopidogrel, and, therefore, there does not appear to be a reduction in clopidogrel efficacy with the concomitant utilization of these two specific PPIs
This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue
5
Thinking of maybe changing to Pantoprazole or just stopping PPI altogether
3 The FDA issued a strong warning against using omeprazole and esomeprazole with clopidogrel because of the potentially decreased effectiveness for clopidogrel
The subgroup analysis of the PPI cohort in the study by Juurlink and others 8 suggested that pantoprazole lacks this interaction with clopidogrel
For example, taking a cough medicine ( antitussive) and a drug to help you sleep (sedative The DDI risk with clopidogrel does not exhibit a class effect, eg, the effects of clopidogrel on cerivastatin versus other statins, the effects of PPIs on clopidogrel (omeprazole and esomeprazole versus pantoprazole and rabeprazole), the effects of rifampicin on clopidogrel versus other P2Y 12 receptor inhibitors (ticagrelor and prasugrel) and Therapy increases risk of Salmonella, Campylobacter, and other infections
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Introduction Antiplatelet agents are widely prescribed anti-thrombotics that reduce cardiovascular events in patients with acute coronary syndromes (ACS) and/or those
However, this potential interaction may
The effects of the combined or separate intake of 20 mg of omeprazole and 75 mg of clopidogrel on the clopidogrel-induced inhibition of platelet aggregation were
Clopidogrel and proton pump inhibitors: interaction—updated advice In light of the most recent evidence, the previous advice on the concomitant use of clopidogrel
The blood thinner Plavix (clopidogrel) poses a serious proton pump inhibitor drug interaction
The European Society of Cardiology states that omeprazole and esomeprazole have the highest probability of clinically significant interactions with clopidogrel compared to other PPIs
New data show that when clopidogrel and omeprazole are taken together, the effectiveness
Ticlopidine
Patient education: Gastroesophageal reflux disease in adults (Beyond the Basics) Antiulcer medications: Mechanism of action, pharmacology, and side effects; Approach to acute upper gastrointestinal bleeding in adults; Approach to refractory gastroesophageal reflux
The p-value for the comparison was 0
3 The FDA issued a strong warning against using omeprazole and esomeprazole with clopidogrel because
Inhibition of platelet aggregation by clopidogrel is entirely due to the active clopidogrel metabolite
In summary an interaction between clopidogrel and PPIs seems to exist for omeprazole and esomeprazole, whereas there are only limited data for rabeprazole
strong or moderate CYP2C19 inhibitors
market in 2010 after it was found to increase a person's risk of heart attack and stroke
Clopidogrel may increase the blood levels of rosuvastatin
How it works
PPI may be given before breakfast and clopidogrel at bedtime, or PPI may be taken before dinner and clopidogrel at lunchtime
Protonix acts on proton pumps in the stomach