Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong Prochlorperazine is a phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting
Tell your doctor about all your current medicines
The risk of prolonging the QT interval on the ECG is important to consider when prescribing antiemetic drugs
Contraindication: QT prolongation or high risk of Torsade de Pointes (e
Uncommon (0
Drowsiness, dizziness, lightheadedness, blurred vision, constipation, or dry mouth may occur
Overall, the evidence for QTc prolongation 6 with typical doses of 4–8 mg appears to be mixed and
Definitions for QT prolongation vary in the literature, but for men QTc >440 msec and for women QTc >470 msec are commonly used
Prochlorperazine comes as a tablet to take by mouth and as a suppository to place in the rectum
The incidence of vomiting may reach 30%, while the incidence of nausea is around 50% among general surgical patients and up to 80% in high-risk groups ( Gan et al
50: Serotonin antagonist 48 Compazine (prochlorperazine) is effective for the short-term treatment of generalized 49 non-psychotic anxiety
Metoclopramide Neuroleptics have long been associated with sudden death and are reported to cause QT prolongation and TdP at therapeutic doses or in overdose (phenothiazines, thioridazine, haloperidol, chlorpromazine, trifluoperazine, pericycline, prochlorperazine, and fluphenazine)
The suggested oral dose for treatment of migraines and headaches in adults is 5 mg or 10 mg, which can be repeated every six to eight hours
Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes
Long QT syndrome (LQTS) is a disorder of myocardial repolarization characterized by a prolonged QT interval on the electrocardiogram (ECG) ( waveform 1 )
Antiemetic agents may help control symptoms, but may also place patients at risk for QTc prolongation
Combination of prochlorperazine with SSRI/SNRI Prochlorperazine is used to treat nervous, emotional, and mental conditions (eg, schizophrenia) and non-psychotic anxiety
Maximum dose: 20 mg/day (2 to 5 years); 25 mg/day (6 to 12 years) Parenteral: Usual dose: 0
A heart signaling disorder is also called a heart conduction disorder
If any of these effects last or get worse, tell your doctor or pharmacist promptly
Clinicians should strive to use antipsychotics or antidepressants with a lower risk of QTc prolongation in patients with multiple risk factors for this adverse event
This is not a complete list of all corrected QT interval (QTc)-prolonging drugs and does not include drugs with either a minor degree or isolated association(s) with QTc prolongation that appear to be safe in most patients but may need to be avoided in patients with congenital long QT syndrome depending upon clinical circumstances
Table 1 lists common drugs which cause QT prolongation and have been associated with torsades de pointes
29) or conditional risk of TdP and whether they should be avoided in patients with congenital long-QT syndrome