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HDL cholesterol is sometimes called "good" cholesterol because higher concentrations of HDL cholesterol in the blood are associated with a reduced risk of heart Fibrates, which include gemfibrozil (Lopid) and fenofibrate, target triglycerides in the
In order to prevent medication errors, resulting in underdosing or
Gemfibrozil, marketed as “Lopid,” and fenofibrate, known as “Tricor,” are
The usual dosage is one tablet taken by mouth twice a day before meals
The primary role of these agents in clinical practice is for the management of hypertriglyceridemia
Patients receiving concomitant statin therapy before crossover continued the statin at the same
Fibricor (fenofibric acid) tablets: 35–105 mg daily
In comparison with gemfibrozil, fenofibrate therapy yielded significantly greater decreases in the total and LDL cholesterol concentrations
20 While gemfibrozil appears to have a significant impact on the metabolism pathway of rosuvastatin, fenofibrate appears to lack a significant interaction
In comparison with gemfibrozil, fenofibrate therapy yielded significantly greater decreases in the total and LDL cholesterol concentrations
The major concern when using a statin-fibrate combination is the potential increased risk for myopathy and rhabdomyolysis
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44% of reviewers reported a positive effect, while 31% reported a negative effect
Other drugs that have the same active ingredients (e
This discrepancy, as yet unexplained, was observed for bezafibrate (BIP an d LEADER trials), fenofibrate (FIELD trial) but also for gemfibrozil (HHS trial)
Hypolipidemic Agents
ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) gemfibrozil will The fibrates, or fibric acid derivatives, act in part to stimulate the activity of peroxisome proliferator-activated receptors (PPARs), which are involved in fatty acid breakdown
Fenofibrate 145 mg (159) View all images
The easiest way Lipofen (fenofibrate) as low as