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Drugs & Vitamins
Uses Warnings Before taking Dosage Side effects Interactions FAQ The Zofran brand name has been discontinued in the U
Ondansetron has rarely been studied in people under 4 years of age
Zofran® (ondansetron) is a medication that prevents nausea and vomiting caused by chemotherapy, radiation or surgery
Go to: Continuing Education Activity Ondansetron is one of the medications most commonly used for the empiric treatment of nausea and vomiting
It is currently available as a generic drug only
Ondansetron has also been prescribed during pregnancy to help with symptoms of nausea and vomiting in pregnancy (NVP)
8 to 15 kg: 2mg orally disintegrating tablet dissolved orally as a single dose
Malaise (generally feeling unwell) and fatigue (tiredness or lack of energy Zofran ODT; Zuplenz; Descriptions
Can Zofran be used during pregnancy? Acute gastroenteritis is defined as a diarrheal disease of rapid onset, with or without nausea, vomiting, fever, or abdominal pain
This calculator is based on the most common age system
Ondansetron for prevention of nausea and vomiting caused by radiation therapy Appropriate studies have not been performed on the relationship of age to the effects of ondansetron in children younger than 4 years of age
It reduces hospital admissions ZOFRAN ® ODT (ondansetron 12 to 17 years of age: 8 mg administered 30 minutes before the start of chemotherapy, with a subsequent 8-mg dose 8 hours after the first dose
The 8-mg dose is taken again 8 hours after the first dose
12 to 17 years of age: 8 mg administered 30 minutes before the start of chemotherapy, with a subsequent 8-mg dose 8 hours after the first dose
ZOFRAN
The appearance of ZOFRAN can differ based on the dosing
It is in a class of medications called 5-HT3 receptor antagonists and works by Use of ondansetron tablets in these age-groups is supported by evidence from adequate and well-controlled studies of ondansetron tablets in adults with additional data from 3 open-label, uncontrolled, non-US trials in 182 pediatric patients aged 4 to 18 years with cancer who were given a variety of cisplatin or noncisplatin regimens [see Dosage For pediatric patients between 6 months and 1 year of age and/or 10 kg or less: Depending on the fluid needs of the patient, ondansetron injection may be diluted in 10 to 50 mL of 5% Dextrose Injection or 0
15 mg/kg over 15 min administered 30 min before chemotherapy, then 4 and 8 hr after first dose; not to exceed 16 mg The dosage for children may also be based on age and weight
Promethazine can be given as an oral tablet, liquid medication, suppository, or injection
5 mg of promethazine per pound of body weight
"Ondansetron taken during pregnancy was not associated with a significantly increased risk of adverse fetal outcomes
Why do The causes of vomiting vary with age and range from relatively benign to potentially life threatening ( see Table: Some Causes of Vomiting in Infants, Children, and Adolescents Some Causes of Vomiting in Infants, Children, and Adolescents )
In a study of 21 pediatric cancer patients (4 to 18 years of age) who received three intravenous doses of 0
4 Years of Age and Younger
2 UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, Nephrology and Hypertension, Neurology, Obstetrics, Gynecology, and Women Zofran is a prescription medication for severe nausea
Adults and children 12 years of age and older—At first, 8 milligrams (mg) taken 30 minutes before starting cancer treatment
The study was a prospective, double-blind, randomized comparison of ondansetron and placebo to control vomiting among children 6 months through 10 years of age
Recommended Dose and Administration of ZOFRAN Injection for Prevention of Postoperative Nausea and Vomiting
It was designed originally for chemotherapy-induced nausea and vomiting
In patients with mild-to-moderate hepatic impairment, clearance is reduced 2-fold and mean Keep the medicine in the foil pouch until you are ready to use it
Ask your healthcare professional how you should dispose of any medicine
Verywell / Nusha Ashjaee Uses of Zofran for Kids Zofran is approved for the prevention of nausea and vomiting in people
Zofran has been approved for children as young as 6 months—but you should never give it to a child without their own prescription
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12 to 17 years of age: 8 mg administered 30 minutes before the start of chemotherapy, with a subsequent 8-mg dose 4 and 8 hours after the first dose
Highlights for ondansetron Ondansetron orally disintegrating tablet is available as a brand-name drug and as a generic drug
However, the
The half-life of an 8-mg tablet or IV dose of ondansetron is around three to four hours
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It is not recommended for use in children with underlying respiratory disease, including those with asthma and other chronic lung diseases
Here’s ondansetron dosage information in adults for prevention of nausea and vomiting caused by radiation therapy
Then administer 8 mg twice a day (every 12 hours) for 1 to 2 days after completion of chemotherapy
Common side effects of Zofran ODT may include: diarrhea or constipation; headache; drowsiness; or
Zofran ODT side effects (more detail) Appropriate studies have not been performed on the relationship of age to the effects of ondansetron in children younger than 4 years of age
Common Trade Names: Zofran; Adult Dosing
15 mg/kg doses, up to a maximum of 16 mg per dose, infused intravenously over 15 minutes
9% Sodium Chloride Injection
Then administer 8 mg twice a day (every 12 hours) for 1
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Use of ondansetron tablets in these age-groups is supported by evidence from adequate and well-controlled studies of ondansetron tablets in adults with additional data from 3 open-label, uncontrolled, non-US trials in 182 pediatric patients aged 4 to 18 years with cancer who were given a variety of cisplatin or noncisplatin regimens [see
The first dose should be administered 30 minutes before the start of emetogenic chemotherapy, with subsequent doses 4 and 8 In patients 1 month to 4 months of age, a longer half-life was observed due to the higher volume of distribution in this age group
The recommended dosage for adult and pediatric patients 6 months of age and older for prevention of nausea and vomiting associated with emetogenic chemotherapy is 0