Dexamethasone for pain flare

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  • It is thought to be caused by periostial edema after radiotherapy
  • We aimed to compare the efficacy of
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  • 4% (SD±57) incidence of pain and/or
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  • Studies have shown dexamethasone in single doses (0
  • Although the statistical difference was

    The oral corticosteroid dexamethasone significantly decreased flares of bone pain when added to radiation therapy in patients with metastatic cancer

    The overall benefit seen across the full study was largely driven by a reduction in pain flares during the first 5 days, said co-investigator Edward Chow, MD, a professor of radiation

    These crystals can irritate the soft tissues, including the synovial tissue that lines

    Some of the most common side effects of dexamethasone include: fluid retention and swelling

    The questionnaire completion rate was 99 percent for the baseline questionnaire and 82 percent for the ones completed at days 10 and 42

    study design, number of patients, gender, bone location, histological subtype, RT dose

    SAN ANTONIO – Dexamethasone given before radiotherapy for bone metastases reduced the risk for subsequent pain flare by 8

    However, two issues need to be

    Six of 11 (55% with a 95% confidence interval of 23–83%) observed pain flares occurred on day 5

    These medications are widely used because of their overall effectiveness in reducing inflammation--the process that causes the joint pain warmth and swelling of arthritis and related conditions

    Of the 148 patients treated with the steroid, 26

    Seven articles investigated pain flare and/or dexamethasone use for conventional external beam radiation therapy (EBRT) while the remaining four investigated stereotactic body radiation therapy (SBRT)

    The relative risk of reduction of pain flare with dexamethasone compared with placebo in days 0–10 would be 25% in the intention-to-treat and 40% in the sensitivity analyses

    The high-risk patient groups had a 78% chance of developing pain flare, and pain flare despite dexamethasone [OR =24

    The multivariable model for pain flare included 15 variants, with effect sizes ranging from −4

    We conducted a phase II prospective study to investigate the prophylactic role of prolonged

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