In the case of Pseudomonas aeruginosa, essential oils and clotrimazole used alone did not exhibit antimicrobial activities, but the mixtures between clotrimazole and the essential oils of Citrus bergamia or Citrus sinensis exhibited a synergistic antimicrobial effect
Clotrimazole exhibited higher solubility in synthetic oils such as octyldodecanol , which are less affected by changes in pH and ionic strength
Nanostructured lipid carriers (NLCs) are composed of biocompatible and biode-gradable lipids
1) is a relatively less toxic, synthetic, broad-spectrum antifungal agent for the treatment of vaginal infections due to Candida albicans both locally and systemically [1]
As per solubility data of Clotrimazole in different surfactant, maximum amount of drug dissolved in Acrysol K-140 (152
It is soluble in acetone, chloroform, ethyl acetate, and dimethylformamide
The solubility of CTM in various oils was determined to select the oil phase of the microemulsion systems
15) K in four pharmaceutically relevant solvents including buffer pH 2
Nanostructured lipid carriers (NLCs) are composed of biocompatible and biode-gradable lipids
2–313
1021/acs
Preparations of the drug are used both in the topical treatment of dermal infections and to combat vulvovaginal candidiasis
Five salts and two cocrystals of the antimycotic drug clotrimazole (CLT) were crystallized with carboxylic acid coformers adipic acid (ADA), 2,5-dihydroxybenzoic acid (25DHBA), 2,4,6-trihydroxybenzoic acid (246THBA), p -coumaric
It is used to treat vaginal yeast infections, oral thrush, diaper rash, tinea versicolor, and types of ringworm including athlete's foot and jock itch
Determination of Saturation Solubility of CTM in DifferentOils The solubility of CTM in various oils was determined by adding excess amount of drug to 4 g of oil in capped glass test tubes
Ibuprofen (C 13 H 18 O 2, MW 206
, sorbic acid, benzoic acid, methyl and ethyl parabens and the like; about 15-30 mg/g of
It remains stable at higher pH values
Phosphate Buffer 6
1 N NaOH Soluble Determination of Wavelength of Maximum Absorbance max):-