Management of Drug-Drug Interactions With Statins Circulation
Patients who have exhausted prescrip- Considering that the C max and AUC of lovastatin and lovastatin acid were greatly increased by itraconazole, with only a minor effect on their t 1/2,z, as well as the fact that significant quantities of CYP3A4 are present in the gut wall and liver, it is likely that the interaction between lovastatin and itraconazole results mainly from The general design was identical in both studies
Ritonavir
lovastatin
Itraconazole Ketoconazole Levoketoconazole Lopinavir Mibefradil Mifepristone Nefazodone The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive
Hence, the risk of statin-induced myopathy due to CYP3A4 inhibitors appears to be considerably greater for lovastatin and simvastatin compared to the other statins
The proportion of co-medication was 4
Along with other statin drugs, atorvastatin can interact with some prescription and over-the-counter medications
Children younger than 8 years of age—Use and dose must be determined by your doctor
Fluvastatin is a substrate Atorvastatin (Lipitor) is one of the most prescribed medications in the U
The inhibition of the enzyme may result in a serious side effects, especially for the drugs that are Uses for itraconazole
Drug Interactions
Statin medications are used in the management and treatment of hypercholesteremia
g
Coadministration with itraconazole can cause elevated plasma concentrations of these drugs and may Lovastatin belongs to the group of medicines called HMG-CoA reductase inhibitors, or statins
Recommendations for management of clinically significant drug-drug interactions with statins and select agents used in patients with cardiovascular disease