Since chloroquine resistance first emerged independently in Southeast Asia and South America, later spreading from Asia to Africa, scientists have been working to understand the mechanistic basis of drug action and resistance (Supplemental Table 1)
Mechanism of Action
Quinolines / metabolism Quinolines / pharmacology* Antimalarials Hemoglobins Membrane Proteins STOM protein, human Chloroquine The drug chloroquine is bactericidal for Bacillus megaterium; it inhibits DNA and RNA biosynthesis and produces rapid degradation of ribosomes and dissimilation of ribosomal
This review is concerned with the lysosomotropic, anti-inflammatory and immunomodulatory mechanisms of chloroquine, hydroxychloroquine, quinacrine and
The many mechanisms of action of Chloroquine: to use or not to use (in COVID‐19) that is the question Giuseppe Cirino 1 and Amrita Ahluwalia 2 Author
Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine
J Biomol Struct Dyn
Proposed mechanism of chloroquine mechanism of action in the parasite’s food vacuole
Action mechanism of antiviral drugs consists of its transformation to triphosphate following the viral DNA synthesis inhibition
Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the Plasmodium digestive vacuole
76
In contrast to conventional drugs, FQ is the first organometallic drug: a ferrocenyl group covalently flanked by a 4-aminoquinoline and a basic alkylamine
Experimental and modeling studies have shown that chloroquine binds to PfLDH, suggesting that CQ possesses another mechanism of drug action or a mechanism complementary to the one already proposed ,
Chloroquine analogues in drug discovery: new directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases
It is actively concentrated by sensitive intraerythocytic · plasmodia, higher concentrations are found in the infected done, the most frequently prescribed drug
PLAQUENIL (hydroxychloroquine sulfate) is an antimalarial and antirheumatic drug, chemically described as 2- [ [4- [ (7-Chloro-4- quinolyl) amino]pentyl] ethylamino]ethanol sulfate (1:1) with the molecular formula C 18 H 26 ClN 3 O•H 2 SO 4