Sep 14, 2023 · Full Prescribing Information
We showed that single dose oral ondansetron did not prolong the QT interval and resulted in effective use of ORT in children with AGE
• QT Interval Prolongation and Torsade de Pointes: Avoid ZOFRAN in patients with congenital long QT syndrome; monitor with electrocardiograms (ECGs) if concomitant
Conclusions
Ondansetron is safe in regard to QTc prolongation in patients with head trauma
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Infants and Children: Surgical patients: 1 to 4 months: 3
The study reported an overall increase in QT interval following the administration of ondansetron irrespective of the dose administered however, 2 h following the administration, mean QT
75 mg of droperidol, therefore questioning the greater safety of ondansetron when compared to droperidol in the NARRATIVE
In both studies, the investigators concluded that, under controlled conditions, ondansetron induced significantly marked prolongation of the QTc interval
Appropriate studies have not been performed on the relationship of age to the effects of ondansetron in children younger than 4 years of age
Standard dosing to prevent postoperative Ondansetron has been shown to cause headache (27%), malaise/fatigue (13%), and constipation (11%)
crizotinib levels, risk of QT prolongation, cardiac arrhythmias, myelosuppression, other adverse effects (renal transport inhibited, additive effects) Charbit et al
1 Sections of Pediatric Emergency Medicine and A significant medical history (67%) or concomitant use of a QT-prolonging medication (67%) was identified in 83% of reports However, ondansetron is linked with a number of adverse effects, including prolongation of the QT interval
Conclusions: Ondansetron is safe in regard to QTc prolongation in patients with head trauma
The clearance of ondansetron in pediatric patients aged 1 month to 4 months is slower and the half-life is ~2
ZOFRAN is a 5-HT3 receptor antagonist indicated for the prevention of: nausea and vomiting associated with highly emetogenic cancer chemotherapy, including cisplatin greater than or equal to 50 mg/m2
Ondansetron is a widely accepted treatment of nausea and vomiting symptoms after head trauma and concussion in children and teenagers
Congenital long QT syndrome (LQTS) is an inherited disease, it has several forms, and is caused by mutations in the genes encoding specific ion-channel subunits or regulatory proteins