Dilantin, or phenytoin, toxicity happens when you have high levels of Dilantin in your body that become harmful
New disease states can lead to changes in the phenytoin plasma concentration
Dilantin is indicated for the control of generalized tonic-clonic (grand mal) and complex partial (psychomotor, temporal lobe) seizures and prevention and treatment of seizures
Dilantin is indicated for the control of generalized tonic-clonic (grand mal) and complex partial (psychomotor, temporal lobe) seizures and prevention and treatment of
new or worse depression
Evidence Based
1 Adult Dosage - Divided daily dosage: The recommended starting dose for adult patients who have received no previous treatment is one 100-mg DILANTIN
Drug Facts
Adult starting dose in patients who have received no previous treatment is one 100 mg DILANTIN extended capsule three times a day, with dose adjustments as necessary
Applies to the following strengths: 50 mg/mL; 50 mg; 100 mg; 30 mg; 25
The lethal dose in adults is estimated to be 2 to 5 grams
Seizures may be induced after single intraperitoneal administration of 75 mg/kg bw phenytoin in seven-day-old rats, while doses of about 200 mg/kg bw are required in 18-day-old rats
DILANTIN (phenytoin sodium) Page 7 of 38 adults is estimated to be 2 to 5 grams
The estimated lethal dose of methamphetamine is about 200 mg, or 0
It is in the anticonvulsants class of drugs
Periodic measurement of serum phenytoin concentrations should be performed during pregnancy, and the DILANTIN dosage should be adjusted as necessary
Brainstem reflexes were absent until pentobarbital concentrations fell significantly Toxicity relating to phenytoin can be a product of dose misuse, dose adjustment, an interaction with other drugs, or a patient's changing physiology (Kang et al
Description
Postpartum restoration of the original dosage will probably be indicated The lethal dose in pediatric patients is not known
The lethal dose in pediatric patients is not known
8 L/kg
Overdose occurs when someone takes more than the normal or recommended amount of this medicine
Potentially life-threatening symptoms of overdose included seizures (55%), Glasgow Coma Scale ≤8 (20%), hypotension (12%), and wide complex tachycardia (WCT) and cardiac arrest (6%)
The lethal dose in pediatric patients is not known
Maintenance dose: 5 - 7 mg/kg/day (but adjust for severe hypoalbuminemia) One more important note about dosing
Phenobarbital is included in a class of drugs called barbiturates
For oral dosage form (suspension): Adults—At first, 5 milliliters (mL) or one teaspoonful 3 times a day
20–29 kg: 900 mg/day 29