Domperidone is one of the most commonly prescribed drugs for vomiting due to acute gastroenteritis in children, even if not clearly recommended
Acute gastroenteritis is caused by viral, bacterial or protozoal infections
In Qatar in 2008, 40,000 patients were presented to the Pediatric Emergency Center for acute gastroenteritis, 10% of The aim of the present study was to compare the effect of metoclopramide and ondansetron treatments on the emergency department observation time in acute gastroenteritis-related nausea and vomiting (NV)
A review of the literature shows side effects of promethazine, prochlorperazine, and metoclopramide are common and potentially dangerous
The short half-life of this drug necessitates frequent dosing
Alternatively, initial dose of up to 2 mg/kg via intermittent infusion over at least 15 minutes, may be given before cancer therapy and repeated at 2-hourly intervals
Antiemetic drugs including promethazine, prochlorperazine, metoclopramide, ondansetron, and domperidone are readily used in the emergency departments (EDs)
Methods: A randomized, double-blind, placebo-controlled, parallel-group study was conducted in three groups of 12 patients each, receiving either a single i
15 mg/kg, 0
We performed a systematic search of PubMed and bibliographies of relevant review Background
Gastroenteritis can be caused by various viral, bacterial, or parasitic pathogens Gastroenteritis, also known as infectious diarrhea or simply as gastro, is an inflammation of the gastrointestinal tract including the stomach and intestine
S
Although rare, worrisome adverse effects such as drowsiness, Acute viral gastroenteritis should be differentiated from bacterial causes of acute gastroenteritis (e
Hemorrhagic Gastroenteritis, renamed Acute Hemorrhagic Diarrhea Syndrome (AHDS) is a disease often without a Gastric motility may be a concern in these dogs, as hypoperfusion can cause decreased motility
Emerg Infect Dis metoclopramide was the suggested default rescue medication
dopamine (D2) receptor antagonist, which increases upper gastrointestinal motility, contractility, and lower esophageal sphincter tone, causing increased gastric emptying
Domperidone
Ondansetron is the only intervention that revealed an effect on the cessation of vomiting, on preventing hospitalizations, and in reducing the need for intravenous rehydration
Ondansetron is a 5-hydroxytryptamine antagonist that has been used in children as young as 1 month of age for Ondansetron is an oral medication that can treat nausea, including pregnancy-related nausea and gastroenteritis with N/V symptoms
100% of reviewers reported a positive effect, while 0% reported a negative effect
Metoclopramide is also used off-label to treat acute migraine in the emergency department
Metoclopramide hydrochloride (metoclopramide monohydrochloride monohydrate), is a white or almost white crystalline powder, freely soluble in water
3-2% of pregnancies and is defined by dehydration, ketonuria, and more than 5% body weight loss
This study aimed to evaluate the efficacy of metoclopramide for gastric visualization in patients with active UGIB
Citation 55 , Citation 99 The first double blind, randomized, controlled study, in 1979, was published by Van Eygen and colleagues
It is used to help diagnose certain problems in the stomach or intestines
Admission rates were 5
Metoclopramide is commonly used to treat vomiting caused by seasickness and acute gastroenteritis on cruise ships and serious adverse effects have not been reported from use at sea
Intravenous The initial two doses should be 2 mg/kg if highly emetogenic drugs such as cisplatin or dacarbazine are used alone or in combination
Chemicals can also cause gastroenteritis
Metoclopramide is a dopamine receptor antagonist and has been approved by the FDA to treat nausea and vomiting in
One study 25 found
Intravenous metoclopramide (Reglan) and intravenous, intramuscular, or rectal prochlorperazine (Compazine) are recommended for treatment of patients with
take anti-vomiting medication (such as metoclopramide) and/or antidiarrhoeal medication (such as loperamide) if you need to – some types are
Therapeutic options available for adults with vomiting secondary to gastroenteritis include dopamine antagonists such as metoclopramide or
Currently, metoclopramide is the only US FDA-approved medication for the treatment of gastroparesis
Metoclopramide can
Adult: 10 mg up to tid via slow IV inj over at least 3 minutes or IM inj
Elderly: Dose reduction may be needed
Antiemetic drugs including promethazine, prochlorperazine, metoclopramide, ondansetron, and domperidone are readily used in the emergency departments (EDs)
Metoclopramide
Gastroenteritis, also known as infectious diarrhea or simply as gastro, is an inflammation of the gastrointestinal tract including the stomach and intestine
Acute viral gastroenteritis should be differentiated from bacterial causes of acute gastroenteritis (e
Gastroenteritis is a common childhood illness that causes vomiting, diarrhoea and fever, often in sporadic seasonal outbreaks
Given its widespread use and growing concern about toxicity in this population, we conducted a systematic review of metoclopramide for the treatment of gastroesophageal reflux disease in
Metoclopramide may be used short-term for the treatment of gastrointestinal reflux disease that is unresponsive to other medications or to treat diabetic stasis
Gastroenteritis
Emerg Infect Dis metoclopramide was the suggested default rescue medication
Mechanism of action
Acute gastroenteritis is the most common cause of physician visits and hospitalizations in infants and young children
Metoclopramide
Materials and Methods: A double-blind trial including consecutive consented patients ages 1 to 14 years was conducted in an urban infirmary setting from