Safety and efficacy have not been established
Glipizide and glimepiride are preferred agents in this setting
Common brands include: Chlorpropamide (marketed as Diabinese) Glipizide (marketed as Glucotrol) Glyburide (marketed as DiaBeta) Glimepiride (marketed as Amaryl) Meglitinides stimulate a shorter term
The medication is available as a generic
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While glyburide use in these patients has decreased significantly, there are still elderly patients with impaired renal function receiving the drug
39–1
Cohort Sulfonylurea + metformin vs
The absorption of glipizide is delayed by food; in contrast • Consider short-acting agents (i
particularly in the elderly or patients with multiple other medical problems and when the medication is not promptly withdrawn Glyburide belongs to a class of medicines called sulfonylureas
One hundred forty-five patients aged > or = 65 years with NIDDM that was controlled for at least 3 months with oral sulfonylurea therapy were enrolled
unusual tiredness or weakness
, glipizide) to reduce risk of hypoglycemia • Avoid glyburide because of higher risk of hypoglycemia: Meglitinides • Can skip doses if meals are skipped • Multiple doses before each meal increase pill burden ATP-regulated K channels in beta cells are a hetero-multimeric complex of both Kir 6
Micronized glyburide: Initial dose: 1
75 to 12 mg orally as a single dose Glipizide (Oral Route) In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do
glyburide (generic) +
Find medical information for glyburide on epocrates online, including its dosing, contraindications, drug interactions, and pill pictures
2011; 17 (9):664–71
Maintenance dose: 5 to 10 mg orally once a day
Elderly: Glyburide is a longer-duration sulfonylurea; avoid use in older adults due to potential for severe hypoglycemia (Beers Criteria [AGS 2019])
Glyburide and glimepiride have been linked to more severe low blood sugars than glipizide, especially if you’re an older adult or have other health conditions like kidney disease