yellowing of the eyes or skin
Since hydroxyurea inhibits DNA synthesis, it can result in significant toxicity, including myelosuppression
Hydroxyurea Side Effects Serious side effects of Hydroxyurea
The more common side effects of hydroxyurea can include: stomach pain constipation diarrhea nausea vomiting loss of appetite 1
Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or
Check with your doctor right away if you have back, leg, or stomach pains, bleeding gums, chills, dark urine, difficulty breathing, fever, general body swelling
It is one of the earliest drugs that showed promise in the management of
Avoid
Like other drugs, hydroxyurea has risks
Other serious complications of hydroxyurea include bone marrow suppression
Weight gain
Some people who take hydroxyurea may experience these side effects: • Thinning hair or mild hair loss • Fingernail beds that turn darker • Nausea (feeling sick to your stomach) Very rarely, hydroxyurea can cause more serious side effects
Specifically, the risk for agranulocytosis and pancytopenia may be increased Avoid
Hydroxycarbamide (Hydrea) Hydroxycarbamide is a chemotherapy treatment
To examine the risks and benefits of long-term hydroxyurea usage, patients in this trial were followed for 17
It is not intended to be medical advice or a substitute for the Hydroxycarbamide, also known as hydroxyurea, is a medication used in sickle-cell disease, essential thrombocythemia, chronic myelogenous leukemia, polycythemia vera, and cervical cancer
Side effects, drug interactions, warnings, precautions, dosing, storage, pregnancy, and breastfeeding safety information is included
There were no consistent differences in terms of pain alteration, death or adverse events (low-quality evidence) or life-threatening illness
The RCT by Ware et al was of superior methodological quality and reported all relevant details and did not appear to suffer from any biases assessed via the Cochrane risk of
Hydroxyurea is used to prevent painful episodes and reduce the need for blood transfusions in patients with sickle cell anemia
Hydroxyurea capsules can cause fetal harm based on findings from animal studies and the drug’s mechanism of action [see Clinical Pharmacology (12
Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for
Although induction of neutropenia may play some role in the beneficial effects of hydroxyurea for SCA, the follow-up study The hematological effects of hydroxyurea therapy are important for obtaining clinical benefits, but also are the parameters used for dose escalation to MTD
Hydroxyurea is used to prevent painful episodes and reduce the need for blood transfusions in patients with sickle cell anemia