3595
Hydroxyurea is probably a safer drug than 5azacytidine
Three main molecular pathways have been reported: 1) Epigenetic modifications, transcriptional events and signalling pathways involved in HU-mediated response
You pronounce hydroxycarbamide as
Hydroxyurea (HU) is a widely used cytotoxic agent that is known to induce fetal hemoglobin (HbF) production and is presently used to ameliorate the severity of pain episodes in patients with sickle cell anemia (HbSS)
Mechanism of action of hydroxyurea
Cancer Res, 48 (8):2029-2035, 01 Apr 1988
Hydroxyurea is a well-established inhibitor of ribonucleotide reductase that has a long history of scientific interest
Chemistry and Mechanism of Action: Hydroxyurea is an inhibitor of the ribonucleotide reductase system that catalyzes the rate-limiting step in the de novo biosynthesis of purine and pyrimidine deoxyribonucleotides, that is, the conversion of ribonucleotide diphosphates to their deoxyribonucleoside diphosphate derivatives
It can also cause changes in blood counts, such as a decrease in white blood cells, red blood cells, and platelets
Cancer cells absorb hydroxyurea, which prevents the cancer cell from growing
However, estimates of its effect in terms of clinical outcomes (thrombosis, bleeding, hematologic transformations and mortality) are lacking
4 Though hydroxyurea has been shown to reduce the frequency of vaso-occlusive crises, Mechanism of action
Hydroxyurea (HU) is mostly referred to as an inhibitor of ribonucleotide reductase (RNR) and as the agent that is commonly used to arrest cells in the S-phase of the cycle by inducing replication stress
Hydroxyurea was embryotoxic and teratogenic in rats and rabbits at doses 0
Metabolism provides insight concerning the mechanism