Monitor serum testosterone and estradiol at follow-up visits with a practical target in the female range (testosterone 30 – 100 ng/dl; E2 <200 pg/ml)
Blood samples were collected via percutaneous intravenous catheter at baseline and at T=1,2,3,4,6, and 8 hours post-dosing
This is an issue of concern when it comes to estradiol, since oral estradiol may increase the risk of stroke and blood clots
014 mg patch) in young (average age: 51–52 years) and old (average age: 67–74 years) postmenopausal women [164,165]
b Based on sublingual estradiol having ~2- to 5-fold greater bioavailability than oral estradiol per studies ( Wiki; Sam, 2021 )
Figure 1: Levels of estradiol (E2), progesterone (P4), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) with 2 mg oral micronized estradiol
Sublingual
Generally, estradiol is not used orally, owing to extensive first-pass hepatic metabolism, but this effect can be minimized by sublingual administration and absorption
e
We calculated pharmacokinetic parameters for estradiol (E2) and estrone (E1) of maximum serum concentration, time to maximum serum concentration, terminal half
The results demonstrated that sublingual E2 had a significantly higher peak serum E2 concentration of 144 pg/mL, measured using LC-MS/MS, compared with an
10993031 10
Sublingual is generally considered better
Thakfully I had pushed my prescriber to let me use estradiol cypionate twice weekly, each dose being 5mg per injection
Methods: Single doses of micronized 17 beta-estradiol were administered orally (1 mg, 0
When taking estradiol, the most common side effects include: Changes in hair growth, including hair loss on the scalp and excess hair growth on the face, chest, or back
Children—Use is not recommended
[deleted] • 2 mo
Blood was drawn specifically in the mornings before the first dose of sublingual estradiol for the day
In addition to what we discussed above, we would like to highlight that only 1 mg of sublingual estradiol achieved a higher peak estradiol level and AUC than 1 mg of oral estradiol
The objective of this study was to determine the effectiveness of sublingual and topical compounded bioidentical hormone replacement therapy for the treatment of vasomotor, mood, and other quality-of-life symptoms in post-menopausal women
Methods: Single doses of micronized 17β-estradiol were administered orally (1 mg, 0
Due to variations in hormone dose, interval, and mode of hormone administration, and general inter-individual biological variability, the calculated intervals are fairly wide (Table 1)
1,4-6 Saccharin (C 7 H 5 NO 3 S, MW 183
Estrogen is an effective treatment for relief of hot flashes and for other menopausal symptoms as well
(14 through sublingual route and 2 through intramuscular injection) for