Though classified as a class III antiarrhythmic, it affects all phases of the cardiac action potential
There are multiple reported and well-established side effects of amiodarone therapy such as effects on the thyroid, skin, lungs, nerves, and cornea
[00:00:00] Amiodarone can have a number of different effects on thyroid function including on thyroid hormone production and thyroid hormone action
Amiodarone is widely prescribed, largely due to its efficacy in the management of both supraventricular and ventricular arrhythmias
Amiodarone 40 inhibits the peripheral conversion of T4 to T3, leading to a 25% fall in T3 concentration and a slight rise in T4 and thyrotropin concentrations
It has been suggested that a cumulative dose of at least 380 g of amiodarone is necessary to induce cirrhosis, 3 but a more recent examination of available cases suggests courses as short as 1 to 2 years, and that total doses as low as 55 g and averaging only 280 g may suffice
Physical The effects of amiodarone on thyroid function can be divided into those effects that are intrinsic properties of the drug and those effects that are due to iodine
The recommended daily intake of iodine is about 0
Obtain a baseline chest X-ray and pulmonary-function tests, including diffusion capacity, when amiodarone hydrochloride tablets therapy is initiated
Elimination half-life is 6 months and the metabolites are excreted in bile